CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD93
Family Name Histamine H1 receptor Ligand Terfenadine Family
No. of Seeds 3 No. of Other Members 50
Family Centroid CFAMM00018242 Functional Category Approved Drug
Superfamily Biogenic amine receptor ligand Terfenadine Trihexyphenidyl Superfamily
Class Class 89

Cousin Family NamesSeedsMembers
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha-2 adrenergic receptor ligand opiate Meperidine Family 13 76
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Muscarinic acetylcholine receptor Ligand Flutropium Bromide Fa... 6 45
Delta-type opioid receptor Ligand Loperamide Family 8 55
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Muscarinic acetylcholine receptor Ligand Mepenzolate Family 35 11
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Cholinesterase Inhibitor 4-[4-(benzyloxy)piperidino]butyl-3-fl... 5 18
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Sigma non-opioid intracellular receptor 1 ligand methyl (1R,2S... 4 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Squalene synthase inhibitor 3-[2-(4-phenylphenyl)ethynyl]-1-az... 2 1
C-C chemokine receptor type 5 ligand AC1LAX0N family 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00018227 DAP000330 Approved Drug Fexofenadine
CFAMM00018242 DAP000102 Approved Drug Terfenadine
CFAMM00018271 CHEMBL432527 Bioactive (1S)-1-(4-tert-butylphenyl)-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butan-1-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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