CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD938
Family Name Histamine H1 receptor Ligand Tranilast Family
No. of Seeds 5 No. of Other Members 125
Family Centroid CFAMM00113558 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Histamine H1 receptor Ligand Tranilast Superfamily
Class Class 704

Cousin Family NamesSeedsMembers
Retinoic acid receptor alpha Ligand Tamibarotene Family 5 95
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Prostaglandin G/H synthase 2 Inhibitor Mefenamic Acid Family 7 137
D(4) dopamine receptor Ligand PD-165167 Family 2 96
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Receptor tyrosine-protein kinase erbB-2 Inhibitor Mini-antibod... 1 0
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Glycogen phosphorylase, muscle form Inhibitor 4-{2-[(3-nitrobe... 1 12
Tyrosine-protein phosphatase non-receptor type 1 Ligand 2-(oxa... 3 11
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
MO15-related protein kinase Pfmrk Inhibitor 3-[3-(2-hydroxy-et... 1 6
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
High affinity nerve growth factor receptor and RAF proto-oncog... 3 29
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Transient receptor potential cation channel subfamily V member... 2 29
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 7 18
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Amine oxidase [flavin-containing] A and Mitogen-activated prot... 1 71
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxy-phenyl)-... 1 3
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-(4... 2 6
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 5
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 5 3
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Serine/threonine-protein kinase Chk1 inhibitor N-[2-(dimethyla... 8 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Acrosin and Trypsin-1 inhibitor (4-methylphenyl) 4-(diaminomet... 10 13
Thyroid hormone receptor beta ligand SureCN8800248 family 3 10
Leukotriene A-4 hydrolase inhibitor AGN-PC-0A9QDC family 2 5
Transient receptor potential cation channel subfamily V member... 1 2
3-oxoacyl-[acyl-carrier-protein] synthase 3 inhibitor 2-[[4-(4... 1 0
Prostaglandin D2 receptor 2 ligand 2-[4-methoxy-3-[2-[[(1S)-1-... 5 28
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor ethyl ... 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C8 liga... 2 0
Androgen receptor ligand 9-ethoxy-10-methoxy-4-methyl-1H-chrom... 3 4
Androgen receptor ligand tert-butyl 4-methyl-2,5-dioxo-1H-chro... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Prostaglandin E2 receptor EP1 subtype ligand 3-acetamido-5-[2-... 5 1
Leukotriene A-4 hydrolase inhibitor 4-[[(1S,5R)-3-[4-(2-fluoro... 2 2
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 2
Capsid scaffolding protein inhibitor AC1MHP20 family 3 3
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8797384 f... 1 0
Leukotriene B4 receptor 1 ligand 4-methoxy-3-[[(E)-3-(4-phenyl... 2 10
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Follicle-stimulating hormone receptor ligand (1-acetyl-2,2,4-t... 1 2
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 0
Vascular endothelial growth factor receptor 2 ligand CHEMBL197... 1 1
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Major prion protein and Microtubule-associated protein tau inh... 2 10
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 4 1
Cytochrome P450 2D6 inhibitor 2-[(3-butoxyphenoxy)methyl]-3-me... 1 0
Multidrug resistance protein 1 inhibitor 3,4,5-trimethoxy-N-(2... 4 0
Aldo-keto reductase family 1 member C3 and Aldo-keto reductase... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3
Nuclear receptor ROR-gamma and Lethal factor ligand NSC211094 ... 1 3
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Amino Acids and Derivatives Metabolite Xanthurenic acid Family 2 0
Amino Acids and Derivatives Metabolite 5-Hydroxy-N-formylkynur... 3 3
Benzoxazoles Metabolite 4-Acetyl-2(3H)-benzoxazolone Family 1 0
Putative NP ZINC05929328 Family 4 1
methoxybenzoate NP (2-hydroxy-6-methoxyquinolin-3-yl)methyl 4-... 2 1
6,7-dimethoxy-2-oxo-1H-quinolin-4-olate NP 4-hydroxy-n-(2-((2-... 2 0
3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1H-indol-2-one ... 3 1
methyl 2-[(7-bromo-1-benzoxepine-4-carbonyl)amino]benzoate NP ... 1 0
3,5-bis[[2-(4-methoxyphenoxy)acetyl]amino]benzoate NP Agn-pc-0... 1 1
[3-[(E)-3-(4-methoxyphenyl)-3-oxoprop-1-enyl]phenyl] N,N-diphe... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00113558 DAP001531 Approved Drug Tranilast
CFAMM00113532 DNC012891 Investigative Drug 2-Fluoro-6-(3-phenoxy-benzoylamino)-benzoic acid
CFAMM00113573 DNC012842 Investigative Drug 2-(3-Phenoxy-benzoylamino)-benzoic acid
CFAMM00113588 DNC012843 Investigative Drug 2-(4-Fluoro-3-phenoxy-benzoylamino)-benzoic acid
CFAMM00113575 DNC009355 Investigative Drug 2-(2-(4-tert-butylphenoxy)acetamido)benzoic acid

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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