CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD94
Family Name 5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant Cyclobenzaprine Family
No. of Seeds 29 No. of Other Members 680
Family Centroid CFAMM00018340 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily 5-hydroxytryptamine receptor, Noradrenergic re-uptake binding Cyclobenzaprine Superfamily
Class Class 90

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake and Serotonin re-uptake Inhibitor Sibu... 7 127
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Nuclear receptor subfamily 1 group I member 3 ligand piperazin... 3 82
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Beta adrenergic receptor Ligand Bretylium Family 3 11
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Dermatan family 1 11
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 2 18
Substance-P receptor Ligand Vestipitant Family 14 137
Zicronapine family 43 62
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Peptide deformylase, mitochondrial Inhibitor [hydroxy(3-phenyl... 1 0
Amine oxidase [flavin-containing] B Inhibitor [(1e)-4-phenylbu... 5 552
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 3 7
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Cytochrome P450 2D6 Inhibitor Gbr 12530 Family 1 35
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Cannabinoid receptor 2 Ligand 4'-(1,1-dimethyl-heptyl)-3,5-dim... 1 190
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Amine oxidase [flavin-containing] A Inhibitor Trans-(+/-)-2-fl... 2 0
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2... 8 13
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Squalene synthase Inhibitor Zwitterionic Sulfobetaine Derivati... 2 20
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 4 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 12 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 2
Cytochrome P450 1B1 and Cytochrome P450 1A2 inhibitor PYRENE f... 3 148
Sigma non-opioid intracellular receptor 1 ligand 2-(3-iodophen... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 3
Sodium-dependent serotonin transporter and Sodium-dependent do... 5 6
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
Transporter and Sodium-dependent dopamine transporter inhibito... 3 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 1 4
5-hydroxytryptamine receptor 7 ligand 5-methyl-6-(6-methyl-5,6... 2 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-003L8Y... 2 4
Histamine H3 receptor and Acetylcholinesterase ligand 1-[4-[[4... 1 2
Sigma non-opioid intracellular receptor 1 ligand 1-[2-[4-[1-ad... 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 5
Histamine H3 receptor ligand SureCN1641166 family 3 0
Histamine H3 receptor ligand 4-[6-(2-pyrrolidin-3-ylethyl)naph... 1 1
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Histamine H3 receptor ligand (3aR,6aR)-2-propan-2-yl-4-[4-(2-p... 6 5
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 7
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 2 8
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
D(1A) dopamine receptor and D(2) dopamine receptor ligand A314... 3 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 2 1
C-C chemokine receptor type 5 ligand 1-[[(3S,4S)-1-(cyclohexyl... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 2
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
D(2) dopamine receptor ligand AGN-PC-041NNJ family 1 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 0
C-X-C chemokine receptor type 3 ligand [4-(2-bromophenyl)pheny... 1 2
Tetralins Metabolite 1,2,3,4,Tetrahydro-1,5,7-trimethylnapthal... 1 19
1-[(E)-3-phenylprop-2-enyl]-4-[[(4S)-4-prop-1-en-2-ylcyclohexe... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00018305 DAP000864 Approved Drug Amitriptyline
CFAMM00018340 DAP000891 Approved Drug Cyclobenzaprine
CFAMM00018373 DAP001073 Approved Drug Phenindamine
CFAMM00018501 DAP000103 Approved Drug Cyproheptadine
CFAMM00019019 CHEMBL152622 Bioactive AC1L52RA
CFAMM00019011 CHEMBL224095 Bioactive SureCN11488300
CFAMM00018377 CHEMBL69256 Bioactive AGN-PC-074GOW
CFAMM00018526 CHEMBL334440 Bioactive 1-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)butyl]piperidine
CFAMM00018585 CHEMBL19544 Bioactive SureCN7371550
CFAMM00018867 CHEMBL593988 Bioactive AGN-PC-076XM5
CFAMM00018325 CHEMBL201525 Bioactive CHEMBL201525
CFAMM00018569 CHEMBL71155 Bioactive AGN-PC-074GOX
CFAMM00018943 CHEMBL135930 Bioactive N,N-dipropyl-3-(1,2,3,4-tetrahydronaphthalen-1-yl)propan-1-amine
CFAMM00018894 CHEMBL560741 Bioactive AGN-PC-073E3M
CFAMM00018509 CHEMBL542029 Bioactive AGN-PC-07C0MC
CFAMM00018523 CHEMBL234881 Bioactive AGN-PC-04URXR
CFAMM00018678 CHEMBL62540 Bioactive SureCN9374660
CFAMM00018822 CHEMBL346230 Bioactive SureCN11258388
CFAMM00018942 CHEMBL135528 Bioactive N,N-dipropyl-4-(1,2,3,4-tetrahydronaphthalen-1-yl)butan-1-amine
CFAMM00018984 CHEMBL305461 Bioactive AGN-PC-074GP7
CFAMM00018663 CHEMBL224855 Bioactive N,N-dimethyl-3-naphthalen-2-ylbutan-1-amine
CFAMM00018710 CHEMBL135530 Bioactive 4-(3,4-dihydronaphthalen-1-yl)-N,N-dipropylbutan-1-amine
CFAMM00018684 CHEMBL19637 Bioactive AGN-PC-022JBJ
CFAMM00018528 CHEMBL554670 Bioactive AGN-PC-07C0N1
CFAMM00018399 DNC010218 Investigative Drug N,N-dimethyl-4,4-diphenylbutan-1-amine
CFAMM00018951 DNC010215 Investigative Drug N,N-Dimethyl-3,3-diphenylpropan-1-amine
CFAMM00018957 DNC009396 Investigative Drug 2-(1-benzyl-1H-inden-3-yl)-N,N-dimethylethanamine
CFAMM00018950 DNC010213 Investigative Drug N,N-dimethyl-2,2-diphenylethanamine
CFAMM00018428 DNC010464 Investigative Drug N,N-dimethyl-2-(2'-methylbiphenyl-3-yl)ethanamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21783 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543