CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Prostaglandin G/H synthase 2 Inhibitor Benzisoxazole Derivative Valdecoxib Family
No. of Seeds 8 No. of Other Members 38
Family Centroid CFAMM00113879 Functional Category Approved Drug with Natural Product
Superfamily Sodium channel ligand Zonisamide, Prostaglandin synthase inhibitor Valdecoxib Superfamily
Class Class 291

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand Benzisoxazole Derivative Risperi... 3 32
Sodium channel protein type 1 subunit alpha ligand sulfonamide... 1 4
Dihydropterin pyrophosphokinase-dihydropteroate synthase Inhib... 3 101
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 159
Sodium-dependent dopamine transporter Inhibitor RTI-336 Family 21 61
Endothelin-1 receptor Ligand BMS-182874 Family 6 10
Acetylcholinesterase and Cholinesterase inhibitor Icopezil mal... 10 14
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 1 2
Nuclear receptor subfamily 4 group A member 2 ligand 6-[4-(2-m... 2 33
Endothelin-1 receptor and Endothelin B receptor ligand N-(3,4-... 3 2
Sodium-dependent dopamine transporter inhibitor 5-[(3S,4R)-3-(... 2 10
Acetylcholinesterase inhibitor SureCN6987022 family 4 11
UDP-3-O-acyl-N-acetylglucosamine deacetylase inhibitor 4-[5-(3... 6 1
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 2 24
Sodium channel protein type 9 subunit alpha ligand (1R,2R)-N-[... 1 16
Metabotropic glutamate receptor 5 ligand AGN-PC-09QIOE family 1 0
Malonyl-CoA decarboxylase, mitochondrial inhibitor (E)-3-[4-[4... 2 0
Malonyl-CoA decarboxylase, mitochondrial inhibitor AGN-PC-00EM... 3 0
Malonyl-CoA decarboxylase, mitochondrial inhibitor 2-[4-(5-ami... 5 0


External ID

Functional Category

Molecule Name

CFAMM00113879 DAP001541 Approved Drug Valdecoxib
CFAMM00113883 CHEMBL371477 Bioactive AGN-PC-075XHT
CFAMM00113874 CHEMBL196041 Bioactive AGN-PC-075XJH
CFAMM00113884 CHEMBL372838 Bioactive Benzenesulfonamide, 4-[3-(4-fluorophenyl)-5-methyl-4-isoxazolyl]-
CFAMM00113835 CHEMBL363180 Bioactive SureCN4805717
CFAMM00113856 DNC005237 Investigative Drug 5-Methyl-3,4-diphenyl-isoxazole
CFAMM00113847 DNC002844 Investigative Drug parecoxib
CFAMM00113861 DNC005239 Investigative Drug 5-Ethyl-3,4-diphenyl-isoxazole

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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