CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD948
Family Name Mast/stem cell growth factor receptor Kit and Vascular endothelial growth factor receptor 2 Ligand Pazopanib Hcl Family
No. of Seeds 6 No. of Other Members 34
Family Centroid CFAMM00114038 Functional Category Approved Drug
Superfamily Mast/stem cell growth factor receptor Kit and Vascular endothelial growth factor receptor 2 Ligand Pazopanib Hcl Superfamily
Class Class 712

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 13 100
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BIUF2 family 25 11
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 0
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 5
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
5-hydroxytryptamine receptor 6 ligand 3-(benzenesulfonyl)-N,5-... 4 1
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 2 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 3 5
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK2 and ALK tyrosine kinase receptor ... 5 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-0CSEAG family 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
C-C chemokine receptor type 3 and Cytochrome P450 2D6 ligand 1... 5 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-b]pyridazine d... 2 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 2 1
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 2 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Muscarinic acetylcholine receptor M1 and Cytochrome P450 2C9 l... 2 5
Glucocorticoid receptor ligand N-ethyl-4-fluoro-N-[3,3,3-trifl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00114038 DAP001550 Approved Drug Pazopanib HCl
CFAMM00114006 CHEMBL476572 Bioactive AGN-PC-04UHGF
CFAMM00114025 CHEMBL477611 Bioactive SureCN588895
CFAMM00114002 CHEMBL478402 Bioactive AGN-PC-04UHCE
CFAMM00114001 CHEMBL1794074 Bioactive AGN-PC-04UHGD
CFAMM00114029 DCL000351 Clinical Trial Drug Pazopanib

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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