CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD949
Family Name G protein-activated inward rectifier potassium channel 4 Ligand Dalfampridine Family
No. of Seeds 3 No. of Other Members 48
Family Centroid CFAMM00114078 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily G protein-activated inward rectifier potassium channel 4 Ligand Dalfampridine Superfamily
Class Class 713

Cousin Family NamesSeedsMembers
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
SUR2-type K(ATP) channel Ligand Pinacidil Family 1 8
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Serine/threonine-protein kinase receptor R3 Ligand ACE-041 Family 1 0
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Ribonucleoside-diphosphate reductase large subunit Inhibitor T... 1 1
Peptide deformylase, mitochondrial Inhibitor Hydroxy[3-(6-meth... 1 0
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
5-hydroxytryptamine receptor 7 Ligand 2-[1-(2-chloro-phenyl)-1... 1 1
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Farnesyl pyrophosphate synthase Inhibitor Piridronic Acid Family 3 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 22
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 4-(met... 4 15
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Fatty-acid amide hydrolase 1 Inhibitor 6-fluoropyridin-3-ylbor... 1 2
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Tyrosinase Inhibitor 5-(pyridin-4-yl)-1,3,4-thiadiazole-2(3h)-... 1 1
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 4
Metabotropic glutamate receptor 5 ligand [18F]FDEGPECO family 5 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
S-adenosylmethionine decarboxylase proenzyme inhibitor 6-[(E)-... 2 6
Metabotropic glutamate receptor 5 ligand AGN-PC-075X3R family 1 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 1
Farnesyl pyrophosphate synthase inhibitor AC1NQOV1 family 2 1
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
D(3) dopamine receptor and D(4) dopamine receptor ligand (7S)-... 1 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
Nuclear receptor ROR-gamma and Prelamin-A/C ligand 13463-41-7 ... 1 7
Acetylcholinesterase and Cholinesterase inhibitor 1-pyridin-4-... 1 1
Ras-related protein Rab-9A and Niemann-Pick C1 protein inhibit... 1 2
Nonstructural protein 1 and Cruzipain inhibitor CHEMBL1331578 ... 1 2
Tyrosyl-DNA phosphodiesterase 1 and Inositol monophosphatase 1... 1 3
Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... 1 0
Potassium voltage-gated channel subfamily A member 5 and Inter... 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 4
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Nitric oxide synthase, brain inhibitor SureCN1387416 family 2 0
Azoles Metabolite 2,5-Dimethyl-1H-pyrrole Family 1 4
Azoles Metabolite 1H-Pyrrolo[2,1-c][1,4]thiazine Family 1 1
N-[2-(1-oxidopyridin-1-ium-2-yl)ethyl]-N-phenylacetamide NP 2-... 1 2
Putative NP ZINC19701930 Family 2 2
1,5-dioxidopyrrolo[3,2-c]pyridin-5-ium NP Agn-pc-0639xa Family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00114078 DAP001551 Approved Drug Dalfampridine
CFAMM00114092 DNCL002618 Clinical Trial Drug Picoplatin
CFAMM00114048 DNC014067 Investigative Drug N-methyl-2-(pyridin-2-yl)ethanamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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