CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Cystic fibrosis transmembrane conductance regulator and Anoctamin-1 Inhibitor Crofelemer Family
No. of Seeds 12 No. of Other Members 74
Family Centroid CFAMM00114717 Functional Category Approved Drug with Natural Product
Superfamily Cystic fibrosis transmembrane conductance regulator and Anoctamin-1 Inhibitor Crofelemer Superfamily
Class Class 721

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand Benzisoxazole Derivative Risperi... 3 32
Amine oxidase [flavin-containing] A inhibitor hydrazine antide... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 159
Prolyl endopeptidase inhibitor benzyl (2S)-2-[(2S)-2-(5-phenyl... 6 2
Acetylcholinesterase and Cholinesterase inhibitor Icopezil mal... 10 14
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 10
P2X purinoceptor 7 inhibitor N-[[2-chloro-3-(trifluoromethyl)p... 2 20
D(4) dopamine receptor ligand AGN-PC-087ZJG family 3 13
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 3
Nuclear receptor subfamily 4 group A member 2 ligand 6-[4-(2-m... 2 33
Acetylcholinesterase inhibitor SureCN6987022 family 4 11
Transient receptor potential cation channel subfamily V member... 7 36
Serine/threonine-protein kinase D1 inhibitor SureCN935843 family 2 3
Transient receptor potential cation channel subfamily V member... 12 0
Cathepsin K and Cathepsin L1 inhibitor N-[1-(cyanomethylcarbam... 1 1
Protease inhibitor AC1O53DF family 8 1
Cannabinoid receptor 2 ligand N-(1-adamantyl)-5-(2-pentoxyphen... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 4
Nuclear receptor subfamily 4 group A member 2 and Metabotropic... 2 16
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 2
Histone deacetylase 6 and Histone deacetylase 3 inhibitor AGN-... 4 1
Proteasome subunit beta type-8 inhibitor 5-ethoxy-N-[(2S)-3-me... 1 2
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 6 3
D(3) dopamine receptor and D(4) dopamine receptor ligand 5-[4-... 1 3
Protease inhibitor AC1LALPH family 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[(3aS,6aR)-5-(3... 1 1
Fatty-acid amide hydrolase 1 inhibitor N-[2-(1,3-benzodioxol-5... 1 0
Sodium channel protein type 9 subunit alpha ligand (1R,2R)-N-[... 1 16


External ID

Functional Category

Molecule Name

CFAMM00114717 DNAP001270 Approved Drug Crofelemer
CFAMM00114654 CHEMBL468595 Bioactive AGN-PC-04UGV9
CFAMM00114656 CHEMBL2414033 Bioactive N-cyclohexyl-5-(2-pentoxyphenyl)-1,2-oxazole-3-carboxamide
CFAMM00114761 CHEMBL2414020 Bioactive N-(1-adamantyl)-5-(2-propoxyphenyl)-1,2-oxazole-3-carboxamide
CFAMM00114760 CHEMBL2414021 Bioactive N-(1-adamantyl)-5-(2-butoxyphenyl)-1,2-oxazole-3-carboxamide
CFAMM00114642 CHEMBL2414036 Bioactive N-cyclooctyl-5-(2-pentoxyphenyl)-1,2-oxazole-3-carboxamide
CFAMM00114736 CHEMBL2414018 Bioactive N-(1-adamantyl)-5-(2-methoxyphenyl)-1,2-oxazole-3-carboxamide
CFAMM00114685 CHEMBL1513353 Bioactive ST50674227
CFAMM00114819 CHEMBL75431 Bioactive SureCN9473094
CFAMM00114789 CHEMBL2414032 Bioactive N-cyclopentyl-5-(2-pentoxyphenyl)-1,2-oxazole-3-carboxamide
CFAMM00114747 CHEMBL467793 Bioactive AGN-PC-04UGVB
CFAMM00114788 CHEMBL2414031 Bioactive N-cyclobutyl-5-(2-pentoxyphenyl)-1,2-oxazole-3-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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