CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD965
Family Name Zucapsacin family
No. of Seeds 7 No. of Other Members 177
Family Centroid CFAMM00115046 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Zucapsacin Superfamily
Class Class 725

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta-2 adrenergic receptor ligand catecholamine Orciprenaline ... 13 13
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Oxytocin receptor Ligand Oxytocin Family 30 182
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Muscarinic acetylcholine receptor M3 Ligand Darifenacin Family 3 17
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Renin Inhibitor Aliskiren Family 28 107
Thymopentin family 20 133
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 2A Ligand Pimavanserin Family 4 23
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Elagolix family 43 98
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Vasopeptidase Inhibitor Fasidotril Family 3 7
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
Histamine H3 receptor Ligand UCL-2138 Family 23 172
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
5-hydroxytryptamine receptor 2A Ligand Phenethylamine Family 3 25
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Histamine H3 receptor Ligand A-349821 Family 49 228
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(3,5-dimethoxyphenethyl)oleami... 5 49
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Angiopoietin-1 receptor and Cyclin-dependent kinase 1 Inhibito... 2 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Tubulin beta chain Inhibitor 6-ile-ustiloxin Family 4 3
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase and Urokinase-type plasminogen activator I... 1 3
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Lethal factor Inhibitor N-(3,4,5-trihydroxyphenethyl)oleamide ... 1 3
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Fatty-acid amide hydrolase 1 Inhibitor N-butylcarbamic Acid Bi... 9 31
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Fatty-acid amide hydrolase 1 Inhibitor 3-(trifluoromethyl)phen... 3 0
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-butoxy... 1 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
D(2) dopamine receptor Ligand Epidepride Family 31 66
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Tubulin beta chain Inhibitor Colchinol Family 3 109
Tyrosinase Inhibitor N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenz... 3 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Amine oxidase [flavin-containing] A Inhibitor 2-(4-methoxyphen... 2 7
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Transient receptor potential cation channel subfamily V member... 2 6
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 4
Cathepsin K inhibitor [1-(3-methoxyphenyl)-2-methylpropan-2-yl... 2 10
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
Transient receptor potential cation channel subfamily V member... 3 18
Prothrombin inhibitor (2S)-N-[(4-aminocyclohexyl)methyl]-1-[2-... 1 0
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Cellular tumor antigen p53 and Lysine-specific demethylase 4E ... 1 5
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Dipeptidyl peptidase 4 and Seprase inhibitor (2R)-2-[4-[[[(2S)... 17 19
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 1 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 3 0
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand (5Z,8... 4 2
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Transient receptor potential cation channel subfamily V member... 4 40
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Pol polyprotein inhibitor AC1LA3AI family 5 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Neprilysin inhibitor (2S)-4-methoxy-2-[[1-[[(1R,2S)-2-(4-metho... 1 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 4
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Survival motor neuron protein and Thioredoxin glutathione redu... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 0
Potassium voltage-gated channel subfamily H member 2 ligand N-... 1 4
Neuromedin-K receptor ligand SureCN2478117 family 1 0
Prostaglandin E synthase inhibitor AGN-PC-09QKN6 family 1 3
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 1
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Interstitial collagenase and Matrix metalloproteinase-9 inhibi... 2 1
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Sigma non-opioid intracellular receptor 1 ligand (1R,5S)-9-[(4... 3 2
Glutamate carboxypeptidase 2 inhibitor 2-(4-hydroxy-3-methoxyp... 1 4
Dipeptidyl peptidase 4 inhibitor 7-[(3R)-3-amino-4-(2,4,5-trif... 2 0
Beta-lactamase inhibitor CHEMBL1316873 family 1 1
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
Calpain-1 catalytic subunit inhibitor (2E)-2-[(3,4-dihydroxyph... 4 0
Sodium channel protein type 9 subunit alpha ligand (1R,2R)-N-b... 5 0
Adenosine receptor A2a and Adenosine receptor A2b ligand N-(2-... 3 0
Transient receptor potential cation channel subfamily V member... 1 0
Endothelin-converting enzyme 1 inhibitor [[(2S)-5-(2,4-difluor... 1 0
Lysosomal alpha-glucosidase inhibitor MLS000587024 family 1 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor meth... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[(4... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-000I3M family 2 6
Carbonic anhydrase and Carbonic anhydrase 2 inhibitor 2-(3-chl... 2 0
Chymase and Chymotrypsinogen A inhibitor N-[(2S)-4-chloro-3-ox... 1 0
Amino Acids and Derivatives Metabolite Caffeoyl aspartic acid ... 1 0
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1
N-(2,2-dimethyltetrahydro-2H-pyran-4-yl)-4-(4-methoxyphenyl)te... 2 0
Putative NP ZINC04061066 Family 18 0
NP (z)-n-((4-(3,4-dimethoxyphenyl)tetrahydro-2h-pyran-4-yl)met... 3 2
Putative NP ZINC13119705 Family 3 0
3-benzazepin-2-one NP 7,8-dimethoxy-1h-benzo[d]azepin-2(3h)-on... 2 0
1,4,4a,5,6,8a-hexahydropyrimido[4,5-d]pyrimidine-2,7-dione NP ... 12 0
7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]-N-... 1 0
2-(4-hydroxy-3-methoxyphenyl)-1,3-thiazolidine-4-carboxylate N... 4 0
2-hydroxy-N-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]benzam... 1 0
NP (z)-methyl 4-(4-hydroxy-3-methoxybenzylidene)-1-(3-methoxyp... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00115046 DNAP001285 Approved Drug Zucapsacin
CFAMM00115029 DCL000737 Clinical Trial Drug Capsaicin
CFAMM00114981 DNC013419 Investigative Drug 6'-Iodononivamide
CFAMM00115018 DNC008011 Investigative Drug N-oleoyl-dopamine
CFAMM00115034 DNC006020 Investigative Drug N-(4-methoxybenzyl)oleamide
CFAMM00115112 DNC010695 Investigative Drug N-(3-(4-hydroxy-3-methoxyphenyl)propyl)acetamide
CFAMM00114931 DNC008332 Investigative Drug N-(3,4-dihydroxybenzyl)oleamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26238 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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