CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD966
Family Name Nalfurafine Hcl family
No. of Seeds 33 No. of Other Members 107
Family Centroid CFAMM00115279 Functional Category Approved Drug
Superfamily Nalfurafine Hcl Superfamily
Class Class 66

Cousin Family NamesSeedsMembers
Delta-type opioid receptor ligand opiate analog Codeine Family 15 184
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
u-type opioid receptor ligand opiate opiate analog Oxymorphone... 22 105
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
ALKS33 family 3 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 32 30
Delta-type opioid receptor Ligand 6-cinnamoyl-n-methylstephasu... 3 0
Delta-type opioid receptor Ligand Longanine Family 3 0
Mu-type opioid receptor Ligand Cyprodime Family 12 8
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 6 1
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 16 10
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 20 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 13 5
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 28 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Mu-type opioid receptor ligand Morphine-6-glucuronide family 7 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 6 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 18 1
Delta-type opioid receptor and Kappa-type opioid receptor liga... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 6
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 7 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 9 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 6 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 7 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 0
Mu-type opioid receptor and Gastrin/cholecystokinin type B rec... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00115279 DNAP001291 Approved Drug Nalfurafine hcl
CFAMM00115266 CHEMBL491869 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(3-methoxyphenyl)-N-methylprop-2-enamide
CFAMM00115206 CHEMBL293145 Bioactive butyl (E)-4-[[(4aS,7R)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]amino]-4-oxobut-2-enoate
CFAMM00115184 CHEMBL522142 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(3-fluorophenyl)-N-methylprop-2-enamide
CFAMM00115226 CHEMBL297756 Bioactive (E)-N-[(4R,4aS,7R,7aR)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(4-methylphenyl)prop-2-enamide
CFAMM00115157 CHEMBL519367 Bioactive (E)-N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)-N-methylprop-2-enamide
CFAMM00115258 CHEMBL473362 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-phenylprop-2-enamide
CFAMM00115284 CHEMBL271797 Bioactive N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]benzamide
CFAMM00115176 CHEMBL490666 Bioactive (E)-N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-N-methyl-3-phenylprop-2-enamide
CFAMM00115190 CHEMBL410122 Bioactive N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-hydroxybenzamide
CFAMM00115251 CHEMBL484582 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(furan-3-yl)prop-2-enamide
CFAMM00115175 CHEMBL611932 Bioactive N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-4-tert-butylbenzamide;oxalic acid
CFAMM00115224 CHEMBL459979 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-N-methylhex-2-enamide
CFAMM00115203 CHEMBL472410 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-4a-prop-2-enoxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-phenylprop-2-enamide
CFAMM00115263 CHEMBL453495 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-N-methyl-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
CFAMM00115168 CHEMBL297525 Bioactive (E)-N-[(4R,4aS,7R,7aR)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-phenylprop-2-enamide
CFAMM00115223 CHEMBL410526 Bioactive N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-methoxybenzamide
CFAMM00115236 CHEMBL513598 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-(2-methoxyphenyl)prop-2-enamide
CFAMM00115249 CHEMBL491868 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-N-methyl-3-phenylprop-2-enamide
CFAMM00115262 CHEMBL429929 Bioactive N-[(4R,4aS,7S,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-3-methoxybenzamide
CFAMM00115275 CHEMBL503928 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-N-methyl-3-[3-(trifluoromethyl)phenyl]prop-2-enamide
CFAMM00115229 CHEMBL472583 Bioactive [(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-9-hydroxy-7-[[(E)-3-phenylprop-2-enoyl]amino]-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl] acetate
CFAMM00115281 CHEMBL492073 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-N-methyl-3-(3-methylphenyl)prop-2-enamide
CFAMM00115235 CHEMBL489866 Bioactive SureCN7171745
CFAMM00115241 CHEMBL593214 Bioactive N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-4-methylbenzamide;oxalic acid
CFAMM00115254 CHEMBL271815 Bioactive SureCN1744227
CFAMM00115179 CHEMBL458089 Bioactive SureCN4382704
CFAMM00115273 CHEMBL438413 Bioactive (E)-N-[(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl]-4-phenylbut-2-enamide
CFAMM00115288 DNC014121 Investigative Drug beta-funaltrexamine
CFAMM00115215 DNC014434 Investigative Drug NALFURAFINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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