CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD97
Family Name Oestrogen receptor Ligand triphenyl ethylene stilbene derivative Clomifene Family
No. of Seeds 22 No. of Other Members 420
Family Centroid CFAMM00019541 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily Oestrogen receptor ligand Clomifene Chlorotrianisene Superfamily
Class Class 93

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha-1 adrenergic receptor ligand Dextroamphetamine derivativ... 5 29
Beta adrenergic receptor Ligand Levobunolol Family 6 133
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta-1 adrenergic receptor Ligand Metoprolol Family 29 90
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Beta-1 adrenergic receptor Ligand Oxprenolol Family 3 27
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Potassium voltage-gated channel subfamily H member 2 Ligand Am... 2 16
Sodium channel protein type 5 subunit alpha Ligand Mexiletine ... 7 74
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Tyrosinase Inhibitor Monobenzone Family 6 197
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Oestrogen receptor ligand Dienestrol Family 35 440
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Oestrogen receptor Ligand Chlorotrianisene Family 2 102
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Gadoxetate family 1 3
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 4 35
Translocator protein Inhibitor Dextofisopam Family 3 250
Substance-P receptor Ligand Ezlopitant Family 10 207
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Acolbifene family 10 115
Dapoxetine family 3 40
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 2 5
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
Arachidonate 5-lipoxygenase Inhibitor Bw A4C Family 3 18
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Platelet-activating factor receptor Ligand L-652731 Family 5 116
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Glucocorticoid receptor Ligand 1-methoxy-6-phenyl-6h-benzo[c]c... 2 22
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
DNA-dependent protein kinase catalytic subunit Inhibitor 7-pro... 5 49
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Abelson tyrosine-protein kinase 2 Inhibitor 3'',5''-dimethoxy-... 3 9
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Dipeptidyl peptidase 4 Inhibitor (2-chloro-6-phenoxyphenyl)met... 17 24
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 214
NAD(P)H dehydrogenase [quinone] 1 Inhibitor NSC-106547 Family 3 65
Leukotriene A-4 hydrolase Inhibitor 1-butoxy-4-phenoxybenzene ... 3 85
DNA-dependent protein kinase catalytic subunit Inhibitor 2-(4-... 4 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 4-(1,... 3 31
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 4 37
Histamine H3 receptor Ligand 4-isopropyl-2-(phenoxymethyl)morp... 4 10
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Androgen receptor Ligand 3-methoxy-4-(m-tolyloxy)benzonitrile ... 3 29
Androgen receptor Ligand 4-(m-tolyloxy)-2-(trifluoromethyl)ben... 7 65
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 2 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 2
Histamine H3 receptor Ligand 1-(3-(2-(3-methoxyphenoxy)ethoxy)... 3 9
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
Leukotriene A-4 hydrolase Inhibitor (r/s)-2-((4-phenoxyphenoxy... 7 18
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
Amine oxidase [flavin-containing] B Inhibitor 7-fluoro-2-p-tol... 4 11
5-hydroxytryptamine receptor 7 Ligand (r)-8-phenyl-n,n-dipropy... 9 14
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 10 15
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-methoxybenzenemethan... 2 26
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Arachidonate 5-lipoxygenase Inhibitor 2-(4-butoxy-phenyl)-n-hy... 3 9
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
5-hydroxytryptamine receptor 2A Ligand C-(9h-xanthen-9-yl)-met... 3 5
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Prostaglandin G/H synthase 1 Inhibitor 2-(2-methoxyphenyl)-1h-... 1 11
Tyrosinase Inhibitor 1-(3-phenoxypropyl)-4-(piperidin-1-yl)pip... 2 13
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
Androgen receptor Ligand Palodesangren E Family 12 43
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 2 2
Estrogen receptor and Estrogen receptor beta ligand CHEMBL1087... 2 0
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 10 6
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 8 4
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Leukotriene A-4 hydrolase inhibitor 3-[3-(4-benzylphenoxy)prop... 2 0
Sigma non-opioid intracellular receptor 1 and 3-beta-hydroxyst... 15 11
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[2-... 6 15
Survival motor neuron protein and Lysine-specific demethylase ... 1 16
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
Squalene synthase inhibitor 3-[4-[[(E)-ethylideneamino]oxymeth... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 7 0
D(3) dopamine receptor ligand S 14297 family 1 2
Prelamin-A/C and Solute carrier organic anion transporter fami... 1 15
Substance-P receptor ligand AGN-PC-02K8FR family 1 3
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 12 0
Estrogen receptor and Estrogen receptor beta ligand (2R,3R,4S)... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 4
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Histamine H3 receptor ligand 1-[[4-[4-[(1R)-4-(4-methoxyphenox... 2 1
Transporter and 5-hydroxytryptamine receptor 2C ligand CHEMBL1... 5 5
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-(4-... 2 6
5-hydroxytryptamine receptor 1A ligand oxalic acid;(1R,5S)-5-[... 2 0
Estrogen receptor ligand (8S,9R,11S,13S,14S,17S)-11-[4-[2-[2-(... 1 4
Histamine H3 receptor ligand SureCN6071181 family 2 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
5-hydroxytryptamine receptor 7 and Alpha-2C adrenergic recepto... 3 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 4 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 6
Sigma non-opioid intracellular receptor 1 ligand 4-[[1-[(2-bro... 2 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 3 14
Vitamin D3 receptor ligand (1R,3S,5Z)-5-[(2E)-2-[(3aS,7aR)-1-[... 1 2
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Cathepsin B and Cathepsin S inhibitor (4S,5R)-4-(2,3-dimethylp... 1 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 1 0
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Sigma non-opioid intracellular receptor 1 ligand SureCN7450653... 1 0
Sodium-dependent serotonin transporter inhibitor 1-[5-methoxy-... 1 0
Histamine H3 receptor and Histamine H1 receptor ligand AGN-PC-... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 2
Muscleblind-like protein 1 and Ferritin light chain inhibitor ... 1 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 0
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 1
Trace amine-associated receptor 1 ligand SureCN13886619 family 1 1
Trace amine-associated receptor 1 ligand 4-[4-(2-AMINO-ETHYL)-... 1 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 5 3
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 2 1
Histamine H3 receptor and Histamine H1 receptor ligand (NE)-N-... 1 1
Metabotropic glutamate receptor 2 ligand (5R)-3-[[4-(4-ethoxyp... 3 9
Sigma non-opioid intracellular receptor 1 ligand tert-butyl 2-... 1 1
Histamine H3 receptor ligand (NE)-N-[2-[2-(dimethylamino)ethox... 3 2
Leukotriene A-4 hydrolase inhibitor 1-[2-(4-benzylsulfanylphen... 1 1
Beta-lactamase inhibitor AGN-PC-0A9UJZ family 1 3
Cannabinoid receptor 1 and Monoglyceride lipase ligand 4-(4-ph... 4 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 5 3
Benzyloxycarbonyls Metabolite 4-Methoxybenzyl formate Family 1 7
Phenols and Derivatives Metabolite (±)-Flufenprox Family 1 13
Putative NP ZINC04061066 Family 18 0
NP 1-(7-hydroxyspiro[chroman-2,4'-piperidin]-1'-yl)ethanone Fa... 2 0
Putative NP ZINC38201335 Family 8 0
NP N-(4-chlorobenzyl)-n-(3-(4-isopropoxyphenyl)-3-phenylpropyl... 6 0
4-carboxylate NP ZINC04340771 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00019541 DAP001013 Approved Drug Clomifene
CFAMM00019561 DAP000793 Approved Drug Toremifene
CFAMM00019332 DAP000108 Approved Drug Tamoxifen
CFAMM00019271 CHEMBL53316 Bioactive AC1MHPCY
CFAMM00019674 CHEMBL513397 Bioactive 1-[2-[4-(4-phenyl-2,3-dihydro-1-benzoxepin-5-yl)phenoxy]ethyl]azetidine
CFAMM00019483 CHEMBL6318 Bioactive Idoxifene
CFAMM00019260 CHEMBL163478 Bioactive 2-(4-benzylphenoxy)-N,N-dimethylethanamine
CFAMM00019638 CHEMBL954 Bioactive Enclomiphene
CFAMM00019596 CHEMBL1256914 Bioactive N,N,N-Trimethyl-1-(4-trans-stilbenoxy)-2-propylammonium iodide
CFAMM00019211 CHEMBL190631 Bioactive AC1NV97L
CFAMM00019281 CHEMBL303196 Bioactive Tamoxifen Alcohol
CFAMM00019248 CHEMBL10041 Bioactive 4-HT
CFAMM00019554 DNCL002692 Clinical Trial Drug Afimoxifene
CFAMM00019302 DNC011092 Investigative Drug Tamoxifen butyl bromide
CFAMM00019300 DNC011090 Investigative Drug Tamoxifen ethyl bromide
CFAMM00019504 DNC005181 Investigative Drug Etoloxamine
CFAMM00019283 DNC010462 Investigative Drug 2-(Biphenyl-2-yloxy)-N,N-dimethylethanamine
CFAMM00019299 DNC011091 Investigative Drug Tamoxifen isopropyl bromide
CFAMM00019503 DNC005180 Investigative Drug Phenyltoloxamine
CFAMM00019657 DNC006198 Investigative Drug GSK-5182
CFAMM00019501 DNC005184 Investigative Drug 4-[2-(2-Benzyl-phenoxy)-ethyl]-morpholine
CFAMM00019454 DNC011089 Investigative Drug Tamoxifen methyl iodide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

21785 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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