CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFAD982
Family Name Hidrosmin family
No. of Seeds 14 No. of Other Members 61
Family Centroid CFAMM00115689 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily D-alanyl-D-alanine carboxypeptidase inhibitor B-Lactams Superfamily
Class Class 637

Cousin Family NamesSeedsMembers
DNA binder anthracycline analog Doxorubicin family 9 32
DNA topoisomerase 2-beta Inhibitor Etoposide Family 3 29
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Rotenone family 16 107
taste receptor Ligand Cynarin Family 6 124
Agrimophol family 10 22
Salicin family 5 629
Chromomycin A3 family 7 14
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Oxi4503 family 4 27
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Platelet-activating factor receptor Ligand L-652731 Family 5 116
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 2,5-... 2 96
Acetylcholinesterase Inhibitor Territrem B Family 3 21
Endothelin B receptor and Endothelin-1 receptor Ligand PD-1631... 9 13
Protein kinase C alpha type and Protein kinase C beta type Inh... 7 1
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Tubulin beta chain Inhibitor Combretastatin Family 3 5
L-selectin and P-selectin Inhibitor 2,3,4-trihydroxybenzoic Ac... 2 10
Arachidonate 15-lipoxygenase and Arachidonate 5-lipoxygenase I... 3 18
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Sodium/glucose cotransporter 2 Inhibitor Maackiain Family 1 5
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Protein kinase C alpha type and Protein kinase C beta type Inh... 2 1
Protein kinase C alpha type Inhibitor Acetoside Family 5 39
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Squalene monooxygenase Inhibitor Octyl_gallate Family 5 5
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Cytochrome P450 3A4 Inhibitor (8r,8'r,9's)-5-methoxyclusin Family 6 20
Cytochrome P450 3A4 Inhibitor (-)-cubebininolide Family 4 28
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 6
Heat shock cognate 71 kDa protein Inhibitor NSC-119913 Family 2 1
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Acetylcholinesterase Inhibitor 4-formylphenyl-o-beta-d-ribopyr... 2 17
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
72 kDa type IV collagenase Inhibitor Lithospermic Acid Family 1 0
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 6 6
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 7
Protein kinase C theta type and Protein kinase C eta type inhi... 7 4
Endothelin-1 receptor ligand (2S)-2-(1,3-benzodioxol-5-yl)-4-m... 17 0
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-[(1S,3S,5... 2 0
Endothelin-1 receptor ligand SureCN8117947 family 1 3
Eukaryotic initiation factor 4A-I inhibitor methyl (1R,2R,3S,3... 12 1
Estrogen receptor beta and Estrogen receptor ligand SureCN4017... 3 5
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 2 2
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 1 1
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 1 0
Calmodulin inhibitor CHEMBL2408940 family 1 0
Survival motor neuron protein and Prelamin-A/C inhibitor CHEMB... 2 32
Cytochrome P450 3A4 inhibitor 4-[(2E)-6-[(E)-3-hydroxy-2,6-dim... 3 2
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 4 10
Ribosomal protein S6 kinase alpha-3 inhibitor [(2S,3S,4S,5R,6S... 1 0
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[3... 1 4
Prothrombin inhibitor sodium;[3-ethoxycarbonyl-2-[[3-ethoxycar... 1 6
Cholesteryl ester transfer protein inhibitor [8-[(1S)-1-hydrox... 1 0
72 kDa type IV collagenase inhibitor [(2S,3S,4R)-4-(4,5-dihydr... 1 0
Sugar Acids and Derivatives Metabolite 3-Methoxy-4-hydroxyphen... 1 6
Benzopyrans Metabolite (-)-trans-3,4-Dihydro-4,8-dihydroxy-3-m... 1 0
Prenol Lipids Metabolite 13-Hydroxydihydromelleolide Family 3 0
Phenols and Derivatives Metabolite 2-Ethoxy-4-(4-methyl-1,3-di... 1 0
Acenes Metabolite Musanolone D Family 2 1
Acenes Metabolite 1-Hydroxypyrene glucuronide Family 1 2
Putative NP ZINC02398203 Family 1 0
NP (z)-2-(2,3-dimethoxybenzylidene)-3-oxo-2,3-dihydrobenzofura... 9 0
1,3-dimethylcyclohepta[c]furan-8-one NP 6-(4-hydroxy-3-iodo-5-... 13 1
NP 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-6-ethyl-4-oxo-4h-ch... 33 4
NP 2-((3-(3,4-dihydro-2h-benzo[b][1,4]dioxepin-7-yl)-6-ethyl-4... 10 0
4-acetylphenyl (1'S,2'R,6'R,9'R)-dispiro[cyclohexane-1,4'-[3,5... 4 2
NP (z)-6-((4-bromobenzyl)oxy)-2-(3,4-dimethoxybenzylidene)benz... 13 2
benzenesulfonate NP (z)-3-oxo-2-(3,4,5-trimethoxybenzylidene)-... 26 0
NP (2r,3r,4s,5r,6s)-2-(acetoxymethyl)-6-(2-propionylphenoxy)te... 2 3
NP Ethyl 7-((2-chlorobenzoyl)oxy)-3-(2-methoxyphenyl)-4-oxo-4h... 37 1
bromobenzoate NP ZINC09346025 Family 20 0
NP Af-399/42316321 Family 7 0
Putative NP ZINC02424496 Family 5 0
Putative NP ZINC09051797 Family 10 0
Putative NP ZINC09306352 Family 7 0
Putative NP ZINC09575270 Family 7 0
Putative NP ZINC08382321 Family 8 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00115929 DNAP001373 Approved Drug Dosmalfate
CFAMM00115689 DNAP001504 Approved Drug Hidrosmin
CFAMM00115985 DNAP001605 Approved Drug Hesperidin
CFAMM00115819 CHEMBL359962 Bioactive 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-[4-ethyl-2-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]propan-1-one
CFAMM00115907 CHEMBL1159458 Bioactive 1-[4-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3,4,5,6-tetramethyl-3-[(2S,3R,4S,5R)-3,4,5-trihydroxy-2,4,5,6,6-pentamethyloxan-2-yl]oxyoxan-2-yl]oxy-2,6-dihydroxyphenyl]-3-(3-hydroxy-4-methoxyphenyl)propan-1-one
CFAMM00115691 CHEMBL187163 Bioactive 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-[2-hydroxy-4-methyl-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]propan-1-one
CFAMM00115703 DNC013765 Investigative Drug 6-methoxykaempferol 3-O-beta-D-robinobioside
CFAMM00115883 DNC013759 Investigative Drug CIRSIMARIN
CFAMM00115882 DNC013754 Investigative Drug Tamarixetin 3-glucoside-7-sulfate
CFAMM00115670 DNC002677 Investigative Drug Rutin
CFAMM00115842 DNC013986 Investigative Drug isorhamnetin 3-O-rhamnoside
CFAMM00115841 DNC013985 Investigative Drug quercetin 3-O-neohesperidoside
CFAMM00115704 DNC013764 Investigative Drug Patuletin 3-O-beta-D-robinobioside

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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