CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name thyrotropin-releasing hormone analog Taltirelin Family
No. of Seeds 7 No. of Other Members 29
Family Centroid CFAMM00116032 Functional Category Approved Drug with Human Metabolite & Natural Product
Superfamily thyrotropin-releasing hormone analog Taltirelin Superfamily
Class Class 735

Cousin Family NamesSeedsMembers
Prezatide Copper Acetate family 4 86
Polaprezinc family 2 19
Cadherin-2 Inhibitor Exherin Family 2 9
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 11 57
Histamine H3 receptor Ligand GT-2016 Family 4 6
Peptide deformylase inhibitor (2S)-1-[(2R)-2-(cyclopentylmethy... 2 1
Histamine H2 receptor and Histamine H3 receptor ligand N,N'-bi... 2 1


External ID

Functional Category

Molecule Name

CFAMM00116032 DNAP001374 Approved Drug Taltirelin
CFAMM00116019 CHEMBL224730 Bioactive (2S)-1-[(2S)-2-amino-3-(3-methyl-1H-imidazol-3-ium-4-yl)propanoyl]-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CFAMM00116008 CHEMBL223972 Bioactive (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1-methylimidazol-4-yl)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide
CFAMM00116016 CHEMBL390942 Bioactive (2S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1-ethylimidazol-4-yl)-1-oxopropan-2-yl]-6-oxopiperidine-2-carboxamide
CFAMM00116029 CHEMBL39363 Bioactive (2R)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1-methylimidazol-4-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CFAMM00116034 CHEMBL365775 Bioactive (2S)-1-[(2S)-2-amino-3-(3-methylimidazol-4-yl)propanoyl]-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
CFAMM00116005 DNC014804 Investigative Drug PROTIRELIN

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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