CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Interstitial collagenase and Neutrophil collagenase inhibitor (2R,3R)-3-(cyclopentylmethyl)-2-[[[5-(dimethylamino)naphthalen-1-yl]sulfonyl-methylamino]methyl]-N-hydroxy-4-oxo-4-piperidin-1-ylbutanamide family
No. of Seeds 3 No. of Other Members 9
Family Centroid CFAMM00305893 Functional Category Bioactive
Superfamily Neutrophil collagenase and Interstitial collagenase Binder Superfamily
Class Class 905

Cousin Family NamesSeedsMembers
Prothrombin Inhibitor Argatroban Family 5 41
5-hydroxytryptamine receptor 2A Ligand Fananserin Family 13 49
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor N-(4-s... 12 92
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
5-hydroxytryptamine receptor 6 ligand 1-(5-chloronaphthalen-1-... 1 5
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 6 8
Chymotrypsin-like elastase family member 1 and Neutrophil elas... 1 12
B1 bradykinin receptor ligand SureCN1712821 family 5 3
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
B1 bradykinin receptor and B2 bradykinin receptor ligand SureC... 1 1
C-C chemokine receptor type 8 ligand 3-pyrrolidin-1-ylpropyl 4... 2 0
Microbial collagenase inhibitor AGN-PC-00F1J7 family 4 2
B1 bradykinin receptor ligand AGN-PC-04TG1P family 4 1
Prothrombin and Proteinase-activated receptor 1 ligand (2S)-N-... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Prothrombin inhibitor (2S)-3-[4-[amino(hydrazinyl)methyl]pheny... 1 0
Histidinol dehydrogenase inhibitor 2-(1-benzyl-2-oxo-5-thiomor... 1 4


External ID

Functional Category

Molecule Name

CFAMM00305893 CHEMBL100100 Bioactive (2R,3R)-3-(cyclopentylmethyl)-2-[[[5-(dimethylamino)naphthalen-1-yl]sulfonyl-methylamino]methyl]-N-hydroxy-4-oxo-4-piperidin-1-ylbutanamide
CFAMM00305895 CHEMBL147655 Bioactive CHEMBL147655
CFAMM00305894 CHEMBL316954 Bioactive (2R,3R)-2-[[[5-(dimethylamino)naphthalen-1-yl]sulfonyl-methylamino]methyl]-N-hydroxy-5-methyl-3-(piperidine-1-carbonyl)hexanamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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