CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10058
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)-1-hexanoyl-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00399277 Functional Category Bioactive
Superfamily Protein farnesyltransferase subunit beta and Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Binder Superfamily 4
Class Class 1033

Cousin Family NamesSeedsMembers
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
ABC294640 family 5 75
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Prothrombin inhibitor SureCN7371121 family 13 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 3
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Coagulation factor X and Prothrombin inhibitor SureCN8243313 f... 10 8
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Reverse transcriptase/RNaseH inhibitor (4s)-6-chloro-4-cyclopr... 5 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399275 CHEMBL408569 Bioactive AGN-PC-075Z5D
CFAMM00399281 CHEMBL372343 Bioactive AGN-PC-04RRPQ
CFAMM00399274 CHEMBL199921 Bioactive 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)-1-N-butyl-2-N-(pyridin-3-ylmethyl)piperazine-1,2-dicarboxamide
CFAMM00399280 CHEMBL369933 Bioactive 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)-1-(3-methylbutanoyl)-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
CFAMM00399273 CHEMBL201817 Bioactive AGN-PC-075Z5R
CFAMM00399279 CHEMBL378816 Bioactive AGN-PC-075Z5G
CFAMM00399272 CHEMBL372350 Bioactive AGN-PC-075Z7W
CFAMM00399278 CHEMBL381736 Bioactive AGN-PC-075Z4Y
CFAMM00399277 CHEMBL201043 Bioactive 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)-1-hexanoyl-N-(pyridin-3-ylmethyl)piperazine-2-carboxamide
CFAMM00399276 CHEMBL372415 Bioactive AGN-PC-075ZA9

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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