CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10064
Family Name Muscarinic acetylcholine receptor M3 and Muscarinic acetylcholine receptor M2 ligand 1,1-bis(4-fluorophenyl)-3-[(3R)-3-methoxy-1-azabicyclo[2.2.2]octan-3-yl]prop-2-yn-1-ol family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00399312 Functional Category Bioactive
Superfamily Biogenic amine receptor ligand Terfenadine Trihexyphenidyl Superfamily
Class Class 89

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Terfenadine Family 3 50
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
Choline kinase alpha Inhibitor Hemicholinium-3 Family 4 0
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
D(2) dopamine receptor and D(3) dopamine receptor ligand 4-(4-... 1 3
Squalene synthase inhibitor 3-[2-(4-phenylphenyl)ethynyl]-1-az... 2 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 4
C-C chemokine receptor type 1 ligand SureCN9108276 family 1 0
C-C chemokine receptor type 1 ligand SureCN9108965 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399316 CHEMBL383389 Bioactive SureCN5049464
CFAMM00399309 CHEMBL200957 Bioactive AGN-PC-075YZ1
CFAMM00399315 CHEMBL409151 Bioactive (1R)-1-cycloheptyl-3-[(3R)-3-methoxy-1-azabicyclo[2.2.2]octan-3-yl]-1-phenylprop-2-yn-1-ol
CFAMM00399313 CHEMBL264676 Bioactive (1R)-1-cyclooctyl-3-[(3R)-3-methoxy-1-azabicyclo[2.2.2]octan-3-yl]-1-phenylprop-2-yn-1-ol
CFAMM00399312 CHEMBL381878 Bioactive 1,1-bis(4-fluorophenyl)-3-[(3R)-3-methoxy-1-azabicyclo[2.2.2]octan-3-yl]prop-2-yn-1-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27070 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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