CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10075
Family Name Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-diphenyl-2-(sulfamoylamino)propanoyl]-N-[3-(1H-imidazol-5-yl)prop-2-ynyl]pyrrolidine-2-carboxamide family
No. of Seeds 5 No. of Other Members 9
Family Centroid CFAMM00228578 Functional Category Bioactive with Natural Product
Superfamily Mu-type opioid receptor and Survival motor neuron protein Binder Superfamily
Class Class 2757

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Insulin receptor Ligand Insulin, Porcine Family 61 205
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
Plinabulin family 1 0
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Lethal factor Inhibitor GM6001 Family 50 435
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Renin Inhibitor Enalkiren Family 56 44
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Histamine H3 receptor Ligand GT-2016 Family 4 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Prothrombin inhibitor SureCN5856722 family 3 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Prolyl endopeptidase inhibitor SureCN8938520 family 2 1
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
Prelamin-A/C and Lethal(3)malignant brain tumor-like protein 1... 1 1
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Histamine H3 receptor ligand SureCN2878688 family 8 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Prothrombin inhibitor N-(2-aminoethyl)-2-[5-[[3-(benzylsulfony... 17 5
Renin inhibitor (4S)-5-cyclohexyl-2,2-difluoro-4-[[(2S)-3-(1H-... 1 0
Gastrin-releasing peptide receptor ligand (2S)-N-[(2S)-1-[[(2S... 1 0
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3
Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(3,4-dichlor... 2 1
Histamine H4 receptor and Histamine H3 receptor ligand AGN-PC-... 1 2
Glucocorticoid receptor ligand SureCN13513652 family 1 0
Putative NP ZINC40309668 Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399364 CHEMBL200134 Bioactive (2S)-1-[(2R)-2-amino-3,3-diphenylpropanoyl]-N-[3-(5-methyl-1H-imidazol-4-yl)prop-2-ynyl]pyrrolidine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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