CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10078
Family Name Serine/threonine-protein kinase pim-2 and cGMP-dependent protein kinase 1 inhibitor CHEMBL2001751 family
No. of Seeds 8 No. of Other Members 1
Family Centroid CFAMM00162000 Functional Category Bioactive
Superfamily RAC-alpha serine/threonine-protein kinase and Nuclear receptor ROR-gamma Binder Superfamily
Class Class 3208

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Cyclooxygenase Inhibitor Indomethacin Family 6 271
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Indeglitazar family 3 39
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
5-hydroxytryptamine receptor 3A and Neuronal acetylcholine rec... 1 3
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 11
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 4
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 4
Histamine H3 receptor ligand SureCN2784306 family 5 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 3 0
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Somatostatin receptor type 2 ligand SureCN4313450 family 2 25
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 11 11
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase B-raf inhibitor pyrrole-based ... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor N-[(2S)-1-... 2 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
RAC-alpha serine/threonine-protein kinase inhibitor 6-[5-[(2S)... 1 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Neuronal acetylcholine receptor subunit alpha-7 ligand 5-[6-[[... 1 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Acetylcholinesterase and Cholinesterase inhibitor CHEMBL237591... 1 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 1 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Endothelin B receptor and Endothelin-1 receptor ligand N-[(2R)... 12 3
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Glycogen synthase kinase-3 beta inhibitor bip-135 family 3 1
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
Rho-associated protein kinase 2 inhibitor SureCN13457632 family 1 1
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Protein kinase C theta type and Protein kinase C delta type in... 13 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Collagenase 3 inhibitor SureCN1316041 family 4 3
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Amino Acids and Derivatives Metabolite Flazine Family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399375 CHEMBL575811 Bioactive 5-[5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl]-3-(furan-2-ylmethyl)-1,3-dihydroindol-2-one
CFAMM00399374 CHEMBL575631 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(5-methylfuran-2-yl)-1,3-dihydroindol-2-one
CFAMM00399373 CHEMBL426140 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-[2-methyl-1-(5-methylfuran-2-yl)propan-2-yl]-1,3-dihydroindol-2-one
CFAMM00399379 CHEMBL210954 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-[1-(furan-2-yl)-2-methylpropan-2-yl]-1,3-dihydroindol-2-one
CFAMM00399372 CHEMBL573326 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(furan-2-yl)-1,3-dihydroindol-2-one
CFAMM00399378 CHEMBL577797 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-(4,5-dimethylfuran-2-yl)-1,3-dihydroindol-2-one
CFAMM00399371 CHEMBL226849 Bioactive oxindole-pyridine, 36
CFAMM00399377 CHEMBL211065 Bioactive 5-[5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl]-3-[1-(4,5-dimethylfuran-2-yl)-2-methylpropan-2-yl]-1,3-dihydroindol-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543