CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10097
Family Name Cytochrome P450 3A4 and Insulin-like growth factor 1 receptor ligand (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-[4-(dimethylamino)piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one family
No. of Seeds 24 No. of Other Members 57
Family Centroid CFAMM00399512 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Cytochrome P450 3A4 Binder Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Insulin-like growth factor 1 receptor ligand (3E)-4-[2-(4-brom... 5 13
Insulin-like growth factor 1 receptor and Cytochrome P450 3A4 ... 3 0
Insulin-like growth factor 1 receptor and Cytochrome P450 3A4 ... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399484 CHEMBL521271 Bioactive methyl N-[1-[(2E)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperidin-4-yl]carbamate
CFAMM00399530 CHEMBL482101 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399543 CHEMBL459118 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-[4-[4-(morpholine-4-carbonyl)piperazin-1-yl]piperidin-1-yl]-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399497 CHEMBL482126 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholin-4-ylpiperidin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399490 CHEMBL520419 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(4-hydroxypiperidin-1-yl)-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399503 CHEMBL482089 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-[4-(2-hydroxyethoxy)piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399535 CHEMBL401930 Bioactive BMS-536924
CFAMM00399502 CHEMBL502092 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-[4-[(2S,6R)-2,6-dimethylmorpholin-4-yl]piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399548 CHEMBL506169 Bioactive (3E)-3-[6-[4-(4-acetylpiperazin-1-yl)piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]pyridin-2-one
CFAMM00399528 CHEMBL482102 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-[4-(methylamino)piperidin-1-yl]-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399555 CHEMBL474469 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-[4-[(1S,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]piperidin-1-yl]-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399508 CHEMBL499584 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-[4-[4-(2-methoxyacetyl)piperazin-1-yl]piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399534 CHEMBL519132 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-(4-methoxypiperidin-1-yl)-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399488 CHEMBL502778 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-[4-[4-[2-(2-methoxyethoxy)acetyl]piperazin-1-yl]piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399501 CHEMBL505919 Bioactive methyl 4-[1-[(2E)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperidin-4-yl]piperazine-1-carboxylate
CFAMM00399494 CHEMBL451331 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399520 CHEMBL454467 Bioactive (3E)-3-[6-[4-[bis(2-methoxyethyl)amino]piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]pyridin-2-one
CFAMM00399539 CHEMBL450610 Bioactive 2-methoxyethyl 4-[1-[(2E)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperidin-4-yl]piperazine-1-carboxylate
CFAMM00399532 CHEMBL480965 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399545 CHEMBL505652 Bioactive 2-hydroxyethyl 4-[1-[(2E)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperidin-4-yl]piperazine-1-carboxylate
CFAMM00399512 CHEMBL519300 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-[4-(dimethylamino)piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399531 CHEMBL480966 Bioactive N-[1-[(2E)-2-[4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-2-oxopyridin-3-ylidene]-7-methyl-1,3-dihydrobenzimidazol-5-yl]piperidin-4-yl]cyclopropanecarboxamide
CFAMM00399524 CHEMBL510298 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-[4-[4-(cyclopropanecarbonyl)piperazin-1-yl]piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one
CFAMM00399504 CHEMBL482088 Bioactive (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[6-[4-(2-methoxyethoxy)piperidin-1-yl]-4-methyl-1,3-dihydrobenzimidazol-2-ylidene]pyridin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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