CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10112
Family Name Histamine H3 receptor ligand AGN-PC-075YXY family
No. of Seeds 1 No. of Other Members 4
Family Centroid CFAMM00399610 Functional Category Bioactive with Natural Product
Superfamily Beta-2 adrenergic receptor and Histamine H3 receptor Binder Superfamily
Class Class 3281

Cousin Family NamesSeedsMembers
Eluxadoline family 4 85
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Renin Inhibitor Enalkiren Family 56 44
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Nitric oxide synthase, inducible Inhibitor 4-(1h-imidazol-1-yl... 1 7
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Adenosine receptor A1 and Adenosine receptor A2b ligand 2-amin... 4 0
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 2 10
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Histamine H3 receptor ligand AGN-PC-075YUJ family 2 0
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Glutamate receptor ionotropic, NMDA 2B ligand 2-[[4-(4-chlorop... 4 1
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(5-methylpyrazine... 1 0
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 5
Glucagon receptor ligand SureCN2647807 family 3 7
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Glutaminyl-peptide cyclotransferase inhibitor 1-(3,4-dimethoxy... 1 17
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 1 0
Sphingosine 1-phosphate receptor 1 ligand (2S)-2-[[2-(1H-imida... 4 7
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 4 6


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399610 CHEMBL200941 Bioactive AGN-PC-075YXY

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543