CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10114
Family Name Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 inhibitor N-(2-aminoethyl)-5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide family
No. of Seeds 15 No. of Other Members 8
Family Centroid CFAMM00335756 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 11
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 12 85
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 6 11
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(4-methoxyphe... 6 7
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Cellular tumor antigen p53 inhibitor CHEMBL1395891 family 1 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Platelet-activating factor receptor ligand Foropafant family 2 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9PTC family 4 1
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9T4A family 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9T4C family 1 0
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 1
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Vascular endothelial growth factor receptor 2 ligand AC1NS6KN ... 4 5
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
High affinity nerve growth factor receptor and Hepatocyte grow... 6 8
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 2 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL74 family 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 3 10
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399622 CHEMBL2011351 Bioactive N-(3-aminopropyl)-5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide
CFAMM00399621 CHEMBL2011350 Bioactive N-(2-aminoethyl)-5-[2-[(4-piperazin-1-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide
CFAMM00399627 CHEMBL2013167 Bioactive 5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]-N-(2,2,2-trifluoroethyl)pyridine-3-carboxamide
CFAMM00399620 CHEMBL2011359 Bioactive 3-amino-1-[5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridin-3-yl]propan-1-one
CFAMM00399633 CHEMBL2013069 Bioactive 5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide
CFAMM00399625 CHEMBL2011355 Bioactive N-[2-(methylamino)ethyl]-5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide
CFAMM00399618 CHEMBL2013159 Bioactive N-methyl-5-[2-[(4-morpholin-4-ylpyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide
CFAMM00399631 CHEMBL2013168 Bioactive 5-[2-[[4-(4-methylsulfonylpiperazin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-N-(2,2,2-trifluoroethyl)pyridine-3-carboxamide
CFAMM00399624 CHEMBL2011354 Bioactive N-(2-aminoethyl)-5-[2-[[4-(4,4-difluoropiperidin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide
CFAMM00399623 CHEMBL2011356 Bioactive N-(2-aminoethyl)-5-[2-[[4-(morpholin-4-ylmethyl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27036 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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