CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10137
Family Name Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-benzylpiperidin-4-yl)-2-(2,5-dioxo-7-phenoxy-1,3-dihydro-1,4-benzodiazepin-4-yl)-3-methylbutanamide family
No. of Seeds 11 No. of Other Members 4
Family Centroid CFAMM00399766 Functional Category Bioactive with Natural Product
Superfamily Cathepsin K and Cathepsin L1 Binder Superfamily 2
Class Class 2417

Cousin Family NamesSeedsMembers
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Liver carboxylesterase 1 Inhibitor 5-(trifluoromethoxy)-1h-ind... 3 12
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Renin Inhibitor Ro-66-1168 Family 10 30
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
D(2) dopamine receptor Ligand Epidepride Family 31 66
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 28 91
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Kappa-type opioid receptor ligand AGN-PC-09M90I family 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Renin inhibitor 6-[[(2R)-1-[4-[3-[(2-methoxyphenyl)methoxy]pro... 3 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 2
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Substance-P receptor ligand (2S,4S)-1-N-(3-chlorophenyl)-2-N-[... 5 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Vasopressin V1b receptor ligand AGN-PC-09QGT9 family 4 123
Leukotriene A-4 hydrolase inhibitor AGN-PC-0A9QDC family 2 5
Vasopressin V1b receptor ligand AGN-PC-00HJ2S family 4 6
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
5-hydroxytryptamine receptor 1B ligand SureCN5352760 family 2 5
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor SureC... 2 3
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltra... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Poly [ADP-ribose] polymerase 1 inhibitor N-ethyl-4-[4-[(8-meth... 1 0
Ghrelin/growth hormone secretagogue receptor and Cytochrome P4... 5 20
Serine/threonine-protein kinase Chk1 inhibitor 2-[9-(4-amino-3... 5 2
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 4 11
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 1 2
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Progesterone receptor ligand CHEMBL252850 family 2 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
Histamine H3 receptor and Potassium voltage-gated channel subf... 16 2
Histamine H3 receptor ligand AGN-PC-00AE5Q family 13 13
Leukotriene A-4 hydrolase inhibitor 4-[[(1S,5R)-3-[4-(2-fluoro... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 28 30
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399774 CHEMBL2011834 Bioactive 4-[(2R)-1-[4-[[(1R)-1-cyclohexylethyl]amino]piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-7-phenoxy-1,3-dihydro-1,4-benzodiazepine-2,5-dione
CFAMM00399766 CHEMBL2011816 Bioactive (2R)-N-(1-benzylpiperidin-4-yl)-2-(2,5-dioxo-7-phenoxy-1,3-dihydro-1,4-benzodiazepin-4-yl)-3-methylbutanamide
CFAMM00399781 CHEMBL2011890 Bioactive 4-[(2S)-1-[4-(benzylamino)cyclohexyl]-3-methylbutan-2-yl]-7-phenoxy-1,3-dihydro-1,4-benzodiazepine-2,5-dione
CFAMM00399773 CHEMBL2011835 Bioactive 4-[(2R)-1-[4-(2-cyclohexylethylamino)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-7-phenoxy-1,3-dihydro-1,4-benzodiazepine-2,5-dione
CFAMM00399780 CHEMBL2011894 Bioactive 4-[(2R)-1-[4-(benzylamino)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-7-(2,4-difluorophenoxy)-1,3-dihydro-1,4-benzodiazepine-2,5-dione
CFAMM00399772 CHEMBL2011831 Bioactive 4-[(2R)-1-[4-(benzylamino)piperidin-1-yl]-3-methyl-1-oxobutan-2-yl]-7-phenoxy-1,3-dihydro-1,4-benzodiazepine-2,5-dione
CFAMM00399771 CHEMBL2011832 Bioactive 4-[(2R)-3-methyl-1-oxo-1-[4-[[(1R)-1-phenylethyl]amino]piperidin-1-yl]butan-2-yl]-7-phenoxy-1,3-dihydro-1,4-benzodiazepine-2,5-dione
CFAMM00399778 CHEMBL2011826 Bioactive (2R)-N-(1-benzylpiperidin-4-yl)-2-[7-(2,6-dimethylphenoxy)-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]-3-methylbutanamide
CFAMM00399769 CHEMBL2011818 Bioactive (2R)-N-(1-benzylpiperidin-4-yl)-3-methyl-2-[7-(4-methylphenoxy)-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]butanamide
CFAMM00399777 CHEMBL2011825 Bioactive (2R)-N-(1-benzylpiperidin-4-yl)-2-[7-(4-fluoro-2-methylphenoxy)-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]-3-methylbutanamide
CFAMM00399768 CHEMBL2011819 Bioactive (2R)-N-(1-benzylpiperidin-4-yl)-3-methyl-2-[7-(2-methylphenoxy)-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]butanamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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