CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10145
Family Name Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear factor kappa-B kinase subunit epsilon inhibitor 7-[3-(cyclobutanecarbonylamino)propylamino]-2-[4-(2-piperidin-1-ylethoxy)phenyl]-1H-imidazo[4,5-b]pyridine-6-carboxamide family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00278650 Functional Category Bioactive
Superfamily and Serine/threonine-protein kinase TBK1 Binder Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Adenosine receptor A2a Ligand KW-6002 Family 18 195
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Adenosine receptor A1 and Adenosine receptor A2b ligand 3-meth... 7 19
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-[4-[... 12 15
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 1 2
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Histamine H3 receptor ligand SureCN7251693 family 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Cannabinoid receptor 1 ligand AGN-PC-03I5TW family 3 12
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Adenosine receptor A1 and Adenosine receptor A3 ligand SureCN5... 3 1
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 7
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 1
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Adenosine receptor A1 and Adenosine receptor A2b ligand (2,5-d... 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiest... 7 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2b and Adenosine receptor A2a ligand 1-eth... 5 2
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-07C5TC family 2 4
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-015IFD fa... 2 0
Mitogen-activated protein kinase 14 inhibitor SureCN4838024 fa... 1 0
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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