CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10147
Family Name Beta-secretase 1 inhibitor (5R)-2-amino-5-cyclopropyl-3-methyl-5-[3-(5-prop-1-ynylpyridin-3-yl)phenyl]imidazol-4-one family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00399830 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin D Binder Superfamily 3
Class Class 144

Cousin Family NamesSeedsMembers
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... 3 39
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Beta-secretase 1 and Cathepsin D inhibitor (4R)-2'-amino-6-(2-... 2 3
Beta-secretase 1 and Beta-secretase 2 inhibitor SureCN4964150 ... 3 0


External ID

Functional Category

Molecule Name

CFAMM00399830 CHEMBL2012070 Bioactive (5R)-2-amino-5-cyclopropyl-3-methyl-5-[3-(5-prop-1-ynylpyridin-3-yl)phenyl]imidazol-4-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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