CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10150
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A inhibitor 5-(aminomethyl)-N-[(4-fluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide family
No. of Seeds 27 No. of Other Members 20
Family Centroid CFAMM00399857 Functional Category Bioactive with Natural Product
Superfamily cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor SCH-365351 Superfamily
Class Class 897

Cousin Family NamesSeedsMembers
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
Oestrogen receptor and Estrogen receptor beta Ligand 2-naphtha... 4 51
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... 1 6
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
5-hydroxytryptamine receptor 3A ligand 2-[(3S)-3-ethylmorpholi... 10 18
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and Dual 3',5'... 11 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Rho-associated protein kinase 2 inhibitor SureCN3232097 family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00399867 CHEMBL400976 Bioactive [5-(aminomethyl)-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazol-4-yl]-[4-[(Z)-N-methoxy-C-pyridin-2-ylcarbonimidoyl]piperidin-1-yl]methanone
CFAMM00399880 CHEMBL2012214 Bioactive 5-(aminomethyl)-N-[(2-fluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399873 CHEMBL2012235 Bioactive 5-[(1S)-1-amino-2-methylpropyl]-N-[(2,4-difluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399853 CHEMBL2012222 Bioactive 5-(aminomethyl)-N-[(3,4-difluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399879 CHEMBL2012217 Bioactive 5-(aminomethyl)-N-[(2,6-difluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399846 CHEMBL401345 Bioactive SureCN13918550
CFAMM00399872 CHEMBL2012232 Bioactive 5-[(1S)-1-aminoethyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-N-[(2,4,6-trifluorophenyl)methyl]-1,3-oxazole-4-carboxamide
CFAMM00399852 CHEMBL399385 Bioactive SureCN8274312
CFAMM00399865 CHEMBL2012238 Bioactive 5-[(1R)-1-aminoethyl]-N-[(1S)-2-hydroxy-1-phenylethyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399878 CHEMBL249933 Bioactive SureCN13918620
CFAMM00399845 CHEMBL437020 Bioactive SureCN8274554
CFAMM00399871 CHEMBL2012231 Bioactive 5-[(1S)-1-aminoethyl]-N-[(3,4-difluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399884 CHEMBL2012219 Bioactive 5-(aminomethyl)-N-[(2,4-difluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399851 CHEMBL2012224 Bioactive 5-[(1S)-1-aminoethyl]-N-[(3-fluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399844 CHEMBL250137 Bioactive SureCN13918691
CFAMM00399857 CHEMBL2012208 Bioactive 5-(aminomethyl)-N-[(4-fluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399850 CHEMBL2012225 Bioactive 5-[(1S)-1-aminoethyl]-N-[(2-fluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399876 CHEMBL2012212 Bioactive 5-(aminomethyl)-N-[(3-fluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399856 CHEMBL2012207 Bioactive 5-(aminomethyl)-N-benzyl-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399849 CHEMBL2012226 Bioactive 5-[(1S)-1-aminoethyl]-N-[(2,6-difluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399862 CHEMBL249691 Bioactive SureCN13918530
CFAMM00399875 CHEMBL2012237 Bioactive 5-[(1S)-1-aminoethyl]-N-[(1S)-2-hydroxy-1-phenylethyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399881 CHEMBL399298 Bioactive SureCN8275107
CFAMM00399848 CHEMBL2012228 Bioactive 5-[(1S)-1-aminoethyl]-N-[(2,4-difluorophenyl)methyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide
CFAMM00399874 CHEMBL2012236 Bioactive 5-(aminomethyl)-N-[(1S)-2-hydroxy-1-phenylethyl]-2-[8-methoxy-2-(trifluoromethyl)quinolin-5-yl]-1,3-oxazole-4-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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