CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10158
Family Name Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threonine-protein kinase inhibitor 5-chloro-3-[4-(3-ethyl-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-2-methyl-N-(2-pyrrolidin-1-ylethyl)aniline family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00126940 Functional Category Bioactive
Superfamily RAC-gamma serine/threonine-protein kinase and Ribosomal protein S6 kinase beta-1 Inhibitor XL418 Superfamily
Class Class 819

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
RAC-gamma serine/threonine-protein kinase and Ribosomal protei... 3 5
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Xanthine dehydrogenase/oxidase inhibitor AGN-PC-06VJIZ family 1 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Epidermal growth factor receptor and Tyrosine-protein kinase A... 4 3
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 9 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 3 5
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Fibroblast growth factor receptor 1 and Vascular endothelial g... 5 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Serine/threonine-protein kinase Chk1 inhibitor N'-(8-chloro-3-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26816 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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