CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10164
Family Name Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase inhibitor AGN-PC-00SITN family
No. of Seeds 4 No. of Other Members 19
Family Centroid CFAMM00400029 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Microtubule-associated protein tau Binder Superfamily
Class Class 1503

Cousin Family NamesSeedsMembers
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 11 12
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 0
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Dihydrofolate reductase inhibitor 10-[3-(4-nitrophenoxy)propox... 1 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 6 3
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Dihydrofolate reductase inhibitor 4-[[4-(4,6-diamino-2,2-dimet... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400029 CHEMBL20528 Bioactive AGN-PC-00SITN
CFAMM00400019 CHEMBL6671 Bioactive AGN-PC-00SIT9
CFAMM00400028 CHEMBL20812 Bioactive 80555-82-4
CFAMM00400017 CHEMBL20129 Bioactive AGN-PC-00SITA

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42686 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543