CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10165
Family Name Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-bromophenyl)-2-[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-formylanilino]acetamide family
No. of Seeds 2 No. of Other Members 14
Family Centroid CFAMM00400046 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Beta-secretase 1 Binder Superfamily 3
Class Class 4766

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
HIV protease Inhibitor Saquinavir Family 64 428
Purine nucleoside phosphorylase Inhibitor BCX-34 Family 2 31
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Calcitonin gene-related peptide type 1 receptor ligand CHEMBL1... 5 8
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 11
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Dipeptidyl peptidase 4 inhibitor (2S)-1-[2-[5-(aminomethyl)-2-... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 4 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 6 6
Melanin-concentrating hormone receptor 1 ligand N-[(3S)-1-[[(3... 2 0
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Dipeptidyl peptidase 4 inhibitor 2-[(3R)-3-aminopiperidin-1-yl... 3 4
Motilin receptor ligand SureCN2768052 family 3 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... 3 3
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Angiopoietin-1 receptor and Vascular endothelial growth factor... 1 0
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 1 0
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL3... 1 9
Adenosine receptor A3 and Adenosine receptor A1 ligand 1,3-dim... 1 2
Potassium voltage-gated channel subfamily A member 5 ligand 3-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400046 CHEMBL201293 Bioactive N-(4-bromophenyl)-2-[4-(2,4-dioxo-1,3-dipropyl-5H-pyrrolo[3,2-d]pyrimidin-6-yl)-N-formylanilino]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26223 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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