CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10167
Family Name Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamide family
No. of Seeds 7 No. of Other Members 6
Family Centroid CFAMM00400067 Functional Category Bioactive with Natural Product
Superfamily Neuropeptide Y receptor type 5 and Prelamin-A/C Binder Superfamily 2
Class Class 147

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Prothrombin Inhibitor Ximelegatran Family 8 157
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
Substance-P receptor Ligand GSK424887 Family 8 184
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Histone deacetylase 1 Inhibitor Resminostat Family 2 5
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... 7 6
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-(2,6... 8 60
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 3 1
Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... 2 1
Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... 2 0
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 8
Coagulation factor X and Trypsin-1 inhibitor 2-(5-carbamimidoy... 5 2
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 5 9
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 3
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family 2 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Platelet-activating factor receptor ligand YM-461 family 1 11
Serine/threonine-protein kinase D3 and Protein kinase C delta ... 3 0
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 1 0
Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... 1 0
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... 7 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 3 2
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Coagulation factor X and Prothrombin inhibitor SureCN8237487 f... 16 1
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-(1-... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 18
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor 2-(2,6... 3 10
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family 1 2
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
Cannabinoid receptor 2 ligand 1-(benzenesulfonyl)-N-quinolin-3... 2 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Androgen receptor ligand CHEMBL181722 family 1 1
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor N-(2-b... 1 0
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Coagulation factor X inhibitor (3R,4R)-3-N-[2-fluoro-4-(2-oxop... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
NP Agn-pc-099dao Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400066 CHEMBL2013023 Bioactive 2-(5-fluoroindol-1-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamide
CFAMM00400065 CHEMBL2013025 Bioactive 2-(5,6-difluoroindol-1-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamide
CFAMM00400064 CHEMBL2013024 Bioactive 2-(6-fluoroindol-1-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamide
CFAMM00400063 CHEMBL2013027 Bioactive 2-(2-methylindol-1-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamide
CFAMM00400062 CHEMBL2013026 Bioactive 2-(5-cyanoindol-1-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamide
CFAMM00400061 CHEMBL2013029 Bioactive 2-(1-methylindol-3-yl)-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamide
CFAMM00400067 CHEMBL2013018 Bioactive 2-indol-1-yl-N-[4-[(propan-2-ylsulfonylamino)methyl]cyclohexyl]acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23724 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543