| Cousin Family Names | Seeds | Members |
|---|
| 5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family | 8 | 438 |
| 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... | 14 | 2769 |
| 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... | 4 | 171 |
| D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... | 22 | 170 |
| D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family | 5 | 74 |
| Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... | 26 | 1171 |
| Somatostatin receptor type 2 ligand octapeptide Octreotide Family | 27 | 172 |
| Sodium channel protein type 5 subunit alpha Ligand Disopyramid... | 4 | 352 |
| Gamma-aminobutyric acid A receptor Ligand Bromazepam Family | 2 | 60 |
| Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family | 8 | 328 |
| Prothrombin Inhibitor Ximelegatran Family | 8 | 157 |
| Hepatocyte growth factor receptor Ligand Arq 197 Family | 10 | 400 |
| Glycogen synthase kinase-3 beta and Protein kinase C beta type... | 5 | 53 |
| Neuromedin-K receptor Ligand SB222200 Family | 17 | 235 |
| Calcitonin gene-related peptide type 1 receptor Ligand Telcage... | 25 | 124 |
| Thromboxane A2 receptor Ligand Ramatroban Family | 13 | 49 |
| Substance-P receptor Ligand GSK424887 Family | 8 | 184 |
| 5-hydroxytryptamine receptor 6 Ligand SB-742457 Family | 9 | 66 |
| Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family | 13 | 179 |
| Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family | 5 | 154 |
| Glutamate receptor AMPA subtype Ligand CX-516 Family | 9 | 24 |
| Gamma-aminobutyric acid receptor Ligand E-2007 Family | 7 | 118 |
| Growth hormone receptor Ligand EP-51216 Family | 34 | 390 |
| D(1B) dopamine receptor Ligand LE-300 Family | 65 | 452 |
| Histone deacetylase 1 Inhibitor Panobinostat Family | 5 | 93 |
| D(3) dopamine receptor Ligand SB-277011 Family | 13 | 178 |
| Protein kinase C alpha type and Protein kinase C beta type Inh... | 16 | 86 |
| Histone deacetylase 1 Inhibitor Resminostat Family | 2 | 5 |
| Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family | 6 | 29 |
| Gastrin/cholecystokinin type B receptor Ligand PD136450 Family | 53 | 117 |
| C-C chemokine receptor type 3 Ligand YM-344031 Family | 19 | 106 |
| Lethal factor Inhibitor GM6001 Family | 50 | 435 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... | 4 | 34 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... | 4 | 25 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 6 | 17 |
| Cannabinoid receptor 2 Ligand JWH-167 Family | 25 | 168 |
| Somatostatin receptor type 2 Ligand L-054852 Family | 13 | 88 |
| 5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family | 14 | 21 |
| Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... | 12 | 70 |
| D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... | 6 | 48 |
| Substance-K receptor and Substance-P receptor Ligand L-732138 ... | 8 | 147 |
| 5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... | 5 | 4 |
| Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... | 2 | 0 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... | 9 | 40 |
| Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... | 4 | 21 |
| 5-hydroxytryptamine receptor 6 Ligand E-6837 Family | 22 | 44 |
| Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... | 4 | 8 |
| Cannabinoid receptor 2 Ligand JWH-204 Family | 6 | 10 |
| Cannabinoid receptor 2 Ligand JWH-249 Family | 7 | 13 |
| Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... | 18 | 36 |
| 5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... | 4 | 19 |
| 5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... | 7 | 79 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... | 19 | 64 |
| Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... | 12 | 10 |
| Cholecystokinin receptor type A Ligand VL-0395 Family | 12 | 117 |
| Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... | 24 | 50 |
| Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... | 6 | 24 |
| Transient receptor potential cation channel subfamily V member... | 6 | 23 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... | 37 | 1 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... | 8 | 1 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 14 | 19 |
| Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... | 7 | 7 |
| Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... | 20 | 18 |
| Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... | 10 | 26 |
| Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... | 4 | 13 |
| 5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... | 4 | 22 |
| Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... | 8 | 4 |
| 5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... | 3 | 17 |
| Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... | 4 | 10 |
| Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... | 6 | 14 |
| Angiotensin-converting enzyme and Endothelin-converting enzyme... | 2 | 10 |
| Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... | 19 | 108 |
| Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... | 19 | 32 |
| Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... | 94 | 23 |
| Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... | 6 | 10 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... | 3 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... | 3 | 29 |
| Glutamate receptor 1 Ligand Piriqualone Family | 8 | 67 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... | 3 | 27 |
| Endothelin B receptor Ligand IRL-2500 Family | 34 | 87 |
| Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... | 10 | 19 |
| Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... | 12 | 46 |
| Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 12 | 72 |
| Vasopressin V2 receptor Ligand YM-35278 Family | 33 | 38 |
| Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... | 12 | 160 |
| Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... | 10 | 14 |
| Histone deacetylase Inhibitor ST-5732 Family | 8 | 6 |
| Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... | 42 | 7 |
| Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... | 7 | 6 |
| Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor 2-(2,6... | 8 | 60 |
| Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... | 3 | 5 |
| Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... | 2 | 4 |
| Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... | 2 | 14 |
| Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... | 3 | 1 |
| Glycogen synthase kinase-3 beta and Glycogen synthase kinase-3... | 2 | 1 |
| Prolyl endopeptidase inhibitor [(2S,3aS,7aS)-2-(pyrrole-1-carb... | 2 | 0 |
| 5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... | 1 | 11 |
| Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... | 6 | 2 |
| Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... | 7 | 58 |
| Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... | 17 | 28 |
| Gastrin/cholecystokinin type B receptor and Cholecystokinin re... | 14 | 8 |
| Cathepsin L1 inhibitor Bio2_000267 family | 9 | 1 |
| Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... | 1 | 0 |
| Vascular endothelial growth factor receptor 2 and Receptor-typ... | 7 | 4 |
| Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... | 2 | 0 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 2 | 2 |
| Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... | 3 | 4 |
| Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... | 4 | 3 |
| Sodium-dependent serotonin transporter and Sodium-dependent do... | 10 | 2 |
| Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... | 2 | 14 |
| 5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... | 11 | 20 |
| Histamine H3 receptor ligand AGN-PC-04YWRD family | 5 | 13 |
| Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... | 3 | 1 |
| Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... | 3 | 0 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... | 1 | 1 |
| Cellular tumor antigen p53 and Microtubule-associated protein ... | 1 | 8 |
| Coagulation factor X and Trypsin-1 inhibitor 2-(5-carbamimidoy... | 5 | 2 |
| Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... | 1 | 36 |
| Survival motor neuron protein and Nonstructural protein 1 inhi... | 1 | 18 |
| Mu-type opioid receptor and Kappa-type opioid receptor ligand ... | 1 | 0 |
| 5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... | 2 | 91 |
| Melatonin receptor type 1A and Melatonin receptor type 1C liga... | 2 | 5 |
| Thyroid hormone receptor beta and Microtubule-associated prote... | 1 | 8 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 5 | 9 |
| Disintegrin and metalloproteinase domain-containing protein 17... | 4 | 0 |
| Cellular tumor antigen p53 and Microtubule-associated protein ... | 1 | 3 |
| Mitogen-activated protein kinase 1 and Nonstructural protein 1... | 1 | 33 |
| Survival motor neuron protein and Menin inhibitor CHEMBL151109... | 1 | 11 |
| Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family | 2 | 2 |
| D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 5 | 8 |
| Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... | 2 | 34 |
| 72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... | 2 | 4 |
| Platelet-activating factor receptor ligand YM-461 family | 1 | 11 |
| Serine/threonine-protein kinase D3 and Protein kinase C delta ... | 3 | 0 |
| Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... | 4 | 2 |
| Acetylcholinesterase inhibitor CHEMBL1651131 family | 6 | 9 |
| Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family | 4 | 3 |
| Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family | 5 | 8 |
| Progesterone receptor and Mineralocorticoid receptor ligand AG... | 6 | 1 |
| Sodium-dependent serotonin transporter and Sodium-dependent do... | 1 | 0 |
| Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... | 2 | 6 |
| Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... | 3 | 1 |
| Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... | 4 | 6 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 18 | 3 |
| 5-hydroxytryptamine receptor 6 ligand SureCN3411879 family | 10 | 3 |
| 5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... | 7 | 3 |
| Renin and Potassium voltage-gated channel subfamily H member 2... | 9 | 2 |
| Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... | 1 | 0 |
| Glycogen synthase kinase-3 beta inhibitor 3-(2-bromoacetyl)-4-... | 1 | 0 |
| 5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... | 8 | 4 |
| Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family | 2 | 4 |
| Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... | 1 | 4 |
| Renin and Potassium voltage-gated channel subfamily H member 2... | 13 | 11 |
| Substance-P receptor and Neuromedin-K receptor ligand 2-[3,5-b... | 7 | 0 |
| Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... | 3 | 2 |
| Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... | 4 | 1 |
| Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... | 3 | 8 |
| Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... | 8 | 10 |
| Melanin-concentrating hormone receptor 1 and Melanin-concentra... | 3 | 1 |
| Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... | 3 | 5 |
| Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... | 5 | 5 |
| Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... | 20 | 2 |
| Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... | 6 | 4 |
| Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... | 5 | 8 |
| Prothrombin and Tissue-type plasminogen activator inhibitor 2-... | 4 | 5 |
| Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... | 1 | 0 |
| Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... | 10 | 7 |
| 5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... | 7 | 1 |
| Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... | 2 | 0 |
| Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... | 1 | 0 |
| Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... | 6 | 8 |
| Coagulation factor X and Prothrombin inhibitor SureCN8237487 f... | 16 | 1 |
| RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... | 11 | 4 |
| Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... | 3 | 1 |
| Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... | 3 | 2 |
| 5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... | 1 | 0 |
| Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... | 12 | 4 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand 2-(1-... | 3 | 0 |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... | 2 | 1 |
| Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... | 2 | 14 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... | 2 | 2 |
| Somatostatin receptor type 1 and Somatostatin receptor type 2 ... | 2 | 18 |
| Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... | 2 | 1 |
| Hepatocyte growth factor receptor and Protein-tyrosine kinase ... | 2 | 15 |
| Protein kinase C delta type and Protein kinase C beta type inh... | 4 | 4 |
| CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... | 2 | 0 |
| Bombesin receptor subtype-3 ligand SureCN13887096 family | 3 | 1 |
| Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... | 17 | 13 |
| Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... | 7 | 18 |
| Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... | 11 | 0 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 2 | 2 |
| Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... | 2 | 1 |
| Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... | 5 | 3 |
| Substance-P receptor and Substance-K receptor ligand N-methyl-... | 2 | 2 |
| Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor 2-(2,6... | 3 | 10 |
| Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... | 3 | 1 |
| Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family | 1 | 2 |
| Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... | 2 | 0 |
| Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... | 2 | 0 |
| 72 kDa type IV collagenase and Interstitial collagenase inhibi... | 1 | 1 |
| Sodium-dependent serotonin transporter and D(2) dopamine recep... | 1 | 0 |
| Cannabinoid receptor 2 ligand 1-(benzenesulfonyl)-N-quinolin-3... | 2 | 2 |
| 5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 3 | 4 |
| Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... | 2 | 4 |
| Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family | 6 | 1 |
| 5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family | 1 | 0 |
| Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family | 19 | 25 |
| Androgen receptor ligand CHEMBL181722 family | 1 | 1 |
| Potassium voltage-gated channel subfamily A member 5 and Volta... | 2 | 4 |
| Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor N-(2-b... | 1 | 0 |
| Peptide deformylase and Peptide deformylase 1A, chloroplastic/... | 1 | 1 |
| Coagulation factor X inhibitor (3R,4R)-3-N-[2-fluoro-4-(2-oxop... | 1 | 0 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... | 1 | 0 |
| Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family | 2 | 0 |
| NP Agn-pc-099dao Family | 2 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
|
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
|
