CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10168
Family Name Histamine H3 receptor ligand 1-[4-(1'-cyclobutylspiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl)oxypiperidin-1-yl]-2-methylpropan-1-one family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00400072 Functional Category Bioactive
Superfamily Histamine H3 receptor Binder Superfamily 7
Class Class 142

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2A Ligand Sarpogrelate Family 2 15
Substance-P receptor Ligand Ezlopitant Family 10 207
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Histamine H3 receptor Ligand A-331440 Family 6 7
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 2 8
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Histamine H3 receptor ligand 1'-cyclobutyl-6-(1-ethylsulfonylp... 7 10
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1


External ID

Functional Category

Molecule Name

CFAMM00400073 CHEMBL2013051 Bioactive 1-[4-(1'-cyclobutylspiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl)oxypiperidin-1-yl]ethanone
CFAMM00400072 CHEMBL2013052 Bioactive 1-[4-(1'-cyclobutylspiro[3,4-dihydrochromene-2,4'-piperidine]-6-yl)oxypiperidin-1-yl]-2-methylpropan-1-one
CFAMM00400074 CHEMBL2013048 Bioactive 1'-cyclobutyl-6-piperidin-4-yloxyspiro[3,4-dihydrochromene-2,4'-piperidine]

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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