CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10174
Family Name Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 inhibitor N-(2-aminoethyl)-5-[2-[(3-chloropyridin-2-yl)amino]-1,3-thiazol-5-yl]pyridine-3-carboxamide family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00329645 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
RAF proto-oncogene serine/threonine-protein kinase Inhibitor M... 1 1
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Reverse transcriptase/RNaseH inhibitor AC1LAJTF family 6 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 12 85
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(4-methoxyphe... 6 7
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Cellular tumor antigen p53 inhibitor CHEMBL1395891 family 1 6
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9PTC family 4 1
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9T4A family 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9T4C family 1 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-02WPKX family 2 5
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Metabotropic glutamate receptor 1 ligand SureCN8238239 family 3 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
High affinity nerve growth factor receptor and Hepatocyte grow... 6 8
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HLHQ family 2 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Adenosine receptor A1 ligand SureCN1497799 family 2 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL74 family 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48712 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543