CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10175
Family Name Orexin receptor type 2 and Orexin receptor type 1 ligand (2-methyl-4-phenyl-1,3-thiazol-5-yl)-[2-[[[5-(trifluoromethyl)pyridin-2-yl]amino]methyl]piperidin-1-yl]methanone family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00276342 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Edoxaban Tosylate family 3 3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing... 3 16
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
DNA primase Inhibitor Bay 57-1293 Family 1 2
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Arachidonate 5-lipoxygenase Inhibitor N-(thiazol-2-yl)benzamid... 3 53
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Mitogen-activated protein kinase 11 and Mitogen-activated prot... 10 31
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 12 85
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 8
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
Cellular tumor antigen p53 inhibitor CHEMBL1395891 family 1 6
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Platelet-activating factor receptor ligand Foropafant family 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 13
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9TG5 family 11 10
Metabotropic glutamate receptor 1 ligand AGN-PC-0A9S6C family 10 1
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Coagulation factor X inhibitor 4-[3-[(5-chloropyridin-2-yl)ami... 2 0
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-[2-[(4-mor... 2 3
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Cell division cycle 7-related protein kinase and Protein DBF4 ... 1 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
D(3) dopamine receptor ligand N-[4-[2-[[(6S)-2-amino-4,5,6,7-t... 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Metabotropic glutamate receptor 1 ligand SureCN8238697 family 2 0
Thrombopoietin receptor ligand N-[4-[2-fluoro-3-(trifluorometh... 2 14
High affinity nerve growth factor receptor and Hepatocyte grow... 6 8
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Mitogen-activated protein kinase 14 inhibitor 303163-37-3 family 1 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 2 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 1
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 1
Coagulation factor X inhibitor SureCN1253902 family 2 0
Thrombopoietin receptor ligand (4R)-1-[3-chloro-5-[[4-[2-fluor... 3 8
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 3 10
Tyrosine-protein kinase ABL1 inhibitor AGN-PC-04SU6B family 2 3
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400097 CHEMBL2031503 Bioactive [(2S)-5-fluoro-2-[[[5-(trifluoromethyl)pyridin-2-yl]amino]methyl]piperidin-1-yl]-(2-methyl-5-phenyl-1,3-thiazol-4-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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