CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10177
Family Name Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ionotropic, NMDA 1 ligand 2-phenyl-4-(piperidin-1-ylmethyl)-1H-benzimidazol-5-ol family
No. of Seeds 4 No. of Other Members 11
Family Centroid CFAMM00400104 Functional Category Bioactive
Superfamily Coagulation factor VII and Urokinase-type plasminogen activator Binder Superfamily
Class Class 931

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
JNJ-39439335 family 5 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Tyrosine kinase Inhibitor PKI166 Family 17 198
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 3 6
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Plasma kallikrein and Coagulation factor VII inhibitor 2-[(3E)... 15 49
Coagulation factor VII inhibitor 2-[(3E)-3-(5-carbamimidoyl-1,... 3 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
Coagulation factor VII inhibitor [3-[(5E)-5-(5-carbamimidoyl-1... 3 2
Serine/threonine-protein kinase Chk1 inhibitor 6-chloro-3-(1,3... 4 2
Glutamate receptor ionotropic, NMDA 2B ligand 2-[[4-(4-chlorop... 4 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 5
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Cationic trypsin and Prothrombin inhibitor 2-ketobenzothiazole... 1 3
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Serine/threonine-protein kinase Chk2 inhibitor (6E)-4-fluoro-6... 3 6
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 inhibi... 9 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 1-[(2... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400103 CHEMBL2013197 Bioactive 2-phenyl-4-(pyrrolidin-1-ylmethyl)-1H-benzimidazol-5-ol
CFAMM00400102 CHEMBL2013196 Bioactive 4-(azepan-1-ylmethyl)-2-phenyl-1H-benzimidazol-5-ol
CFAMM00400100 CHEMBL65454 Bioactive SureCN5240113
CFAMM00400104 CHEMBL2013195 Bioactive 2-phenyl-4-(piperidin-1-ylmethyl)-1H-benzimidazol-5-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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