CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10181
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand SureCN6218259 family
No. of Seeds 11 No. of Other Members 3
Family Centroid CFAMM00400156 Functional Category Bioactive
Superfamily 14-alpha sterol demethylase Inhibitor Voriconazole Superfamily
Class Class 627

Cousin Family NamesSeedsMembers
Toll-like receptor 7 Ligand Imiquimod Family 3 237
14-alpha sterol demethylase Inhibitor Voriconazole Family 1 5
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
TOK-001 family 2 7
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
Tyrosine kinase Inhibitor PKI166 Family 17 198
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 19 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 7 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Glucocorticoid receptor ligand SureCN12238714 family 16 4
Glucocorticoid receptor and Progesterone receptor ligand SureC... 6 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400151 CHEMBL201472 Bioactive SureCN6217336
CFAMM00400144 CHEMBL204004 Bioactive SureCN6216908
CFAMM00400143 CHEMBL204003 Bioactive SureCN6218788
CFAMM00400156 CHEMBL383677 Bioactive SureCN6218259
CFAMM00400149 CHEMBL203315 Bioactive SureCN6216069
CFAMM00400155 CHEMBL203437 Bioactive SureCN6217581
CFAMM00400154 CHEMBL382173 Bioactive SureCN6217551
CFAMM00400147 CHEMBL202952 Bioactive SureCN2658839
CFAMM00400153 CHEMBL206196 Bioactive 2-[2-fluoro-5-[7-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]benzonitrile
CFAMM00400146 CHEMBL382005 Bioactive SureCN6217162
CFAMM00400152 CHEMBL436768 Bioactive SureCN6216804

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27063 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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