CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10184
Family Name Vascular endothelial growth factor receptor 2 and Vascular endothelial growth factor receptor 3 ligand 1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-(3,4,5-trimethoxyphenyl)- family
No. of Seeds 2 No. of Other Members 52
Family Centroid CFAMM00062762 Functional Category Bioactive with Natural Product
Superfamily Vascular endothelial growth factor receptor 2 and Glycogen synthase kinase-3 beta Binder Superfamily
Class Class 2498

Cousin Family NamesSeedsMembers
DNA Binder Primaquine Family 3 245
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Multidrug resistance-associated protein 1 Inhibitor Biricodar ... 6 40
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Indeglitazar family 3 39
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
P2X purinoceptor 7 Inhibitor A-740003 Family 2 6
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Prostaglandin G/H synthase 2 Inhibitor L-761000 Family 8 44
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 17
Prelamin-A/C inhibitor 1-[(3,4-dimethoxyphenethyl)amino]-3-(1H... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 7 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... 4 2
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 1 26
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Platelet-activating factor receptor ligand (4R)-2-pyridin-3-yl... 1 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 7 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Survival motor neuron protein and Arachidonate 15-lipoxygenase... 1 2
Leucyl-cystinyl aminopeptidase inhibitor SureCN988709 family 1 14
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 1 1
Smoothened homolog inhibitor N-[amino-[3-(1H-indol-2-yl)anilin... 1 4
Vascular endothelial growth factor receptor 2 ligand SureCN235... 1 1
Aurora kinase A inhibitor SureCN3802792 family 2 3
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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