CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10205
Family Name Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threonine-protein kinase inhibitor 1-[3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-5-(2-pyrrolidin-1-ylethylamino)phenyl]propan-1-one family
No. of Seeds 4 No. of Other Members 0
Family Centroid CFAMM00400377 Functional Category Bioactive
Superfamily Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threonine-protein kinase Binder Superfamily
Class Class 2483

Cousin Family NamesSeedsMembers
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
3-phosphoinositide-dependent protein kinase 1 and Rho-associat... 12 11
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
Casein kinase II subunit alpha inhibitor CHEMBL401945 family 12 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2


External ID

Functional Category

Molecule Name

CFAMM00400376 CHEMBL2016887 Bioactive 3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-N-phenyl-5-(2-pyrrolidin-1-ylethylamino)benzamide
CFAMM00400379 CHEMBL2016889 Bioactive 3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-5-(3,3-dimethylbutyl)-2-methyl-N-(2-pyrrolidin-1-ylethyl)aniline
CFAMM00400378 CHEMBL2016893 Bioactive 1-[3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-5-(2-pyrrolidin-1-ylethylamino)phenyl]-4,4,4-trifluorobutan-1-one
CFAMM00400377 CHEMBL2016892 Bioactive 1-[3-[4-(3-bromo-2H-pyrazolo[3,4-d]pyrimidin-4-yl)piperazin-1-yl]-4-methyl-5-(2-pyrrolidin-1-ylethylamino)phenyl]propan-1-one

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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