CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10209
Family Name Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fluoro-3-[5-[4-(piperidin-1-ylmethyl)benzoyl]-3,4,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-ylidene]quinolin-2-one family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00400400 Functional Category Bioactive
Superfamily Platelet-derived growth factor receptor beta and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
BIBT986 family 7 96
SB989 family 17 91
CC-486 family 7 103
JAK Inhibitor Momelotinib Family 33 83
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Platelet activating factor, putative Inhibitor ABT-491 Family 22 62
Tryptase Inhibitor Babim Family 12 90
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... 4 31
Telomerase reverse transcriptase Inhibitor NSC-745794 Family 3 1
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-57893 Family 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5856722 family 3 16
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-09M45... 8 1
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6202744 family 4 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 6 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family 3 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801305 ... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... 1 0
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Type-1 angiotensin II receptor ligand 7-methyl-N-(2-phenylethy... 2 10
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
5-hydroxytryptamine receptor 2B ligand SureCN1299437 family 6 7
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
C-C chemokine receptor type 5 ligand N-[3-[4-[3-cyclohexyl-5-(... 5 4
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[4-[4-[(... 9 7
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Substance-K receptor ligand SureCN9035669 family 10 5
Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbu... 12 21
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 5 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 2
Beta-secretase 1 inhibitor SureCN8284926 family 2 0
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor CHEM... 1 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-fluorop... 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN3535776 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400401 CHEMBL2016909 Bioactive (3Z)-6-fluoro-3-[5-(2-morpholin-4-ylacetyl)-3,4,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-ylidene]quinolin-2-one
CFAMM00400400 CHEMBL2016905 Bioactive (3Z)-6-fluoro-3-[5-[4-(piperidin-1-ylmethyl)benzoyl]-3,4,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-ylidene]quinolin-2-one
CFAMM00400399 CHEMBL2016904 Bioactive (3Z)-3-[5-[4-(piperidin-1-ylmethyl)benzoyl]-3,4,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-ylidene]quinolin-2-one
CFAMM00400398 CHEMBL2016919 Bioactive (3Z)-6-fluoro-3-[5-(2-piperidin-1-ylacetyl)-3,4,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-ylidene]quinolin-2-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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