CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10210
Family Name Platelet-derived growth factor receptor beta and Vascular endothelial growth factor receptor 2 ligand 3-(1,3-dihydrobenzimidazol-2-ylidene)-4-[(4-ethyl-1-methylpiperidin-2-yl)amino]quinolin-2-one family
No. of Seeds 5 No. of Other Members 12
Family Centroid CFAMM00017605 Functional Category Bioactive
Superfamily Platelet-derived growth factor receptor beta and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Histamine H1 receptor Ligand Emedastine Family 5 115
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Dipeptidyl peptidase 4 Inhibitor Linagliptin Family 10 81
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
BIBT986 family 7 96
SB989 family 17 91
CC-486 family 7 103
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Adenosine receptor A1 and Adenosine receptor A2b Ligand PSB-11... 34 26
Tryptase Inhibitor Babim Family 12 90
Histamine H3 receptor Ligand SCH79687 Family 11 29
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Vascular endothelial growth factor receptor 2 Ligand 6-(1h-ben... 2 5
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A2b Ligand CVT-7124 Family 14 64
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Adenosine receptor A2a Ligand (e,e)-8-(4-phenylbutadien-1-yl)c... 11 43
Telomerase reverse transcriptase Inhibitor NSC-745794 Family 3 1
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SCH-577... 9 29
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Prothrombin inhibitor SureCN5856722 family 3 16
Acetylcholinesterase inhibitor SureCN251059 family 2 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Histone deacetylase 1 and Histone deacetylase 8 inhibitor (E)-... 3 0
Adenosine receptor A1 ligand SureCN10614388 family 5 1
Adenosine receptor A1 ligand 8-(2-amino-4-nitrophenyl)-1,3-dim... 1 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Dipeptidyl peptidase 4 inhibitor Xanthine Analogue 4 family 1 4
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 3
Histamine H4 receptor ligand SureCN602132 family 1 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
Neuropeptide Y receptor type 5 ligand 8-[6-(4-fluorophenyl)-1H... 2 1
Vascular endothelial growth factor receptor 2 and Mitogen-acti... 2 2
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Poly [ADP-ribose] polymerase 1 inhibitor ethyl 4-(4-carbamoyl-... 2 15
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6202744 family 4 2
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Nociceptin receptor and Kappa-type opioid receptor ligand 1-[1... 4 4
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 6 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
Cellular tumor antigen p53 and Thyrotropin receptor ligand CHE... 1 5
Adenosine receptor A3 and Adenosine receptor A1 ligand (8R)-8-... 4 0
Histamine H4 receptor ligand (2Z)-5-chloro-2-[(1-methylpiperid... 2 8
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Transient receptor potential M8 protein ligand 2-[(E)-2-(oxan-... 5 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 18
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 1
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 5 13
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 2
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 3
Smoothened homolog and Sonic hedgehog protein inhibitor N-cycl... 3 2
Sonic hedgehog protein and Smoothened homolog inhibitor N-(4,4... 2 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 10 14
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Histamine H4 receptor and Histamine H3 receptor ligand (E)-[(3... 4 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Histamine H1 receptor and Potassium voltage-gated channel subf... 1 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 10 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 3
Casein kinase II subunit alpha and Serine/threonine-protein ki... 1 5
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 10 6
Cytochrome P450 3A4 and Insulin-like growth factor 1 receptor ... 24 57
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... 2 2
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-00BSP9 ... 6 12
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Smoothened homolog inhibitor N-[4-methyl-3-(5-phenyl-1H-imidaz... 1 0
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547496 f... 2 1
Adenosine receptor A3 ligand 3-(cyclopropylmethyl)-8-methoxy-1... 1 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 2 1
Urokinase plasminogen activator surface receptor ligand ethyl ... 1 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... 1 1
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 10 4
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Dipeptidyl peptidase 4 inhibitor 2-(3-aminopiperidin-1-yl)-3-b... 4 1
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2S)-... 2 2
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 11 5
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[4-[4-[(... 9 7
Substance-K receptor ligand SureCN9035669 family 10 5
Adenosine receptor A1 ligand 3-(4-Aminophenethyl)-8-(3-noradam... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Putative Bioactive N-[(2R)-2-[(2S)-2-(1H-benzimidazol-2-yl)pyr... 2 0
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Aurora kinase B and Aurora kinase A inhibitor 1-cyclohexyl-3-[... 4 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Gonadotropin-releasing hormone receptor and 5-hydroxytryptamin... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... 3 2
Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... 2 1
5-hydroxytryptamine receptor 2B ligand SureCN1299053 family 1 1
Dipeptidyl peptidase 4 inhibitor SureCN5776796 family 1 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor 2-[4-(5-sulfanylidene... 1 1
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 9 0
Cannabinoid receptor 2 ligand [(4S,4aR,8aS)-4-hydroxy-4-phenyl... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
C-C chemokine receptor type 2 ligand N-[(2S,3S)-1-[(2,4-dimeth... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Pyruvate kinase PKM inhibitor 2-(benzimidazol-1-ylmethyl)-6-me... 1 0
Insulin-like growth factor 1 receptor ligand (3E)-4-[2-(4-brom... 5 13
Insulin-like growth factor 1 receptor and Cytochrome P450 3A4 ... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 2
Beta-secretase 1 inhibitor SureCN8284926 family 2 0
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor CHEM... 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN3535776 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400411 CHEMBL2016928 Bioactive (2Z)-N-(3-methylphenyl)-2-(2-oxoquinolin-3-ylidene)-3,4,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-5-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27512 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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