CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10213
Family Name Cell division cycle 7-related protein kinase and Protein DBF4 homolog A inhibitor 2-(2-aminopyridin-4-yl)spiro[5,6-dihydrothieno[3,2-c]pyridine-7,1'-cyclohexane]-4-one family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00400428 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Aurora kinase A Inhibitor ABT-348 Family 20 49
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Muscarinic acetylcholine receptor M1 Ligand Bo(15)pz Family 4 5
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(2... 2 20
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
D(2) dopamine receptor Ligand PD-135146 Family 5 11
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Sonic hedgehog protein inhibitor 3-chloro-N-[4-(methylamino)cy... 2 3
Serine/threonine-protein kinase Chk1 inhibitor SureCN13010134 ... 7 29
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(4-methoxyphe... 6 7
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 8 1
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 9 1
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Gonadotropin-releasing hormone receptor ligand 1-[4-[1-[(2,6-d... 8 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 2
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 8 4
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 7 1
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 15 8
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Caspase-1 inhibitor (3S)-4-oxo-3-[[6-[[4-(quinoxalin-2-ylamino... 5 6
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(6-morp... 2 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(benzen... 4 4
High affinity nerve growth factor receptor and Hepatocyte grow... 6 8
Intercellular adhesion molecule 1 and E-selectin inhibitor Sur... 1 0
Vascular endothelial growth factor receptor 2 ligand Thienopyr... 2 2
Coagulation factor X inhibitor SureCN8290907 family 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Histone deacetylase 1 and Potassium voltage-gated channel subf... 3 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Adenosine receptor A1 ligand SureCN1497799 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor AGN-PC... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand N-... 1 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-03LEDF family 3 4
Ephrin type-B receptor 4 ligand SureCN4473188 family 3 1
Calcitonin gene-related peptide type 1 receptor ligand N-(1-me... 1 3
Mitogen-activated protein kinase kinase kinase 8 inhibitor AGN... 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400428 CHEMBL2017000 Bioactive 2-(2-aminopyridin-4-yl)spiro[5,6-dihydrothieno[3,2-c]pyridine-7,1'-cyclohexane]-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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