CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10214
Family Name cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A and cGMP-inhibited 3',5'-cyclic phosphodiesterase A inhibitor [5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]-morpholin-4-ylmethanone family
No. of Seeds 7 No. of Other Members 7
Family Centroid CFAMM00400436 Functional Category Bioactive
Superfamily cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A and cGMP-inhibited 3',5'-cyclic phosphodiesterase A Binder Superfamily
Class Class 2504

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Dual specificity protein kinase CLK4 and Dual specificity tyro... 1 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
LIM domain kinase 2 and LIM domain kinase 1 inhibitor N-[5-[6-... 1 22
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 2-(3-c... 3 3
TGF-beta receptor type-1 ligand 5-[(5E)-4-(1,3-benzodioxol-5-y... 3 12


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400436 CHEMBL2017059 Bioactive [5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]-morpholin-4-ylmethanone
CFAMM00400442 CHEMBL2017057 Bioactive N-tert-butyl-5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-N-methyl-1,3-thiazole-2-carboxamide
CFAMM00400441 CHEMBL2017065 Bioactive 4-[5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]morpholine
CFAMM00400439 CHEMBL2017067 Bioactive 4-[[5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]methyl]-1,4-oxazepane
CFAMM00400445 CHEMBL2017061 Bioactive 5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-N-(oxan-4-yl)-1,3-thiazole-2-carboxamide
CFAMM00400438 CHEMBL2017066 Bioactive 4-[[5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]methyl]morpholine
CFAMM00400444 CHEMBL2017060 Bioactive [5-(8,9-dimethoxy-5,6-dihydroimidazo[5,1-a]isoquinolin-1-yl)-1,3-thiazol-2-yl]-(1,4-oxazepan-4-yl)methanone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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