CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10221
Family Name Serine/threonine-protein kinase pim-2 and Serine/threonine-protein kinase pim-1 inhibitor N-(2-chlorophenyl)-6-(1H-1,2,4-triazol-5-yl)thieno[3,2-c]quinolin-4-amine family
No. of Seeds 6 No. of Other Members 1
Family Centroid CFAMM00400519 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase pim-1 and Serine/threonine-protein kinase pim-2 Binder Superfamily 4
Class Class 4769

Cousin Family NamesSeedsMembers
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
PF-4217903 family 14 65
PF-3758309 family 1 8
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
Hepatocyte growth factor receptor ligand 5-[(6-thiophen-3-yl-[... 1 1
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Tyrosine-protein kinase JAK2 and Cytochrome P450 3A4 inhibitor... 1 1
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Platelet-activating factor receptor ligand SureCN9378808 family 3 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
P2X purinoceptor 7 inhibitor 2-(2,3-dichlorophenyl)-N-[(2-meth... 4 17
P2X purinoceptor 7 inhibitor 4-(2,3-dichlorophenyl)-N-[(2-thio... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400518 CHEMBL2017326 Bioactive N-(2-chlorophenyl)-6-(1H-1,2,4-triazol-5-yl)thieno[3,4-c]quinolin-4-amine
CFAMM00400516 CHEMBL2017342 Bioactive N-(2-chloro-4-fluorophenyl)-6-(1H-1,2,4-triazol-5-yl)thieno[3,2-c]quinolin-4-amine
CFAMM00400515 CHEMBL2017339 Bioactive N-(3-chlorophenyl)-6-(1H-1,2,4-triazol-5-yl)thieno[3,2-c]quinolin-4-amine
CFAMM00400521 CHEMBL2017328 Bioactive N-(2-chlorophenyl)-6-(1H-1,2,4-triazol-5-yl)thieno[2,3-c]quinolin-4-amine
CFAMM00400520 CHEMBL2017329 Bioactive N-(2-chlorophenyl)-6-(1H-1,2,4-triazol-5-yl)-[1,3]thiazolo[4,5-c]quinolin-4-amine
CFAMM00400519 CHEMBL2017323 Bioactive N-(2-chlorophenyl)-6-(1H-1,2,4-triazol-5-yl)thieno[3,2-c]quinolin-4-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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