CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10230
Family Name Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phenyl-3-propan-2-ylphenyl)carbamoyl]benzamide family
No. of Seeds 2 No. of Other Members 23
Family Centroid CFAMM00400558 Functional Category Bioactive with Natural Product
Superfamily Histone deacetylase 2 and Metabotropic glutamate receptor 5 Binder Superfamily
Class Class 281

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Gamma-aminobutyric acid receptor Ligand 2-(2-amino-phenyl)-6-m... 4 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Integrin beta-3 and Integrin alpha-IIb inhibitor AGN-PC-02INEQ... 6 6
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Prostaglandin D2 receptor 2 ligand SureCN136287 family 1 9
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QMLE family 5 0
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 1 2
Mitogen-activated protein kinase 14 inhibitor N-[2-fluoro-5-[(... 4 5
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
C-C chemokine receptor type 5 ligand dimethyl-[[4-[[7-(4-methy... 7 8
Capsid scaffolding protein inhibitor AC1MHP1L family 3 6
Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)pro... 2 8
Mitogen-activated protein kinase 14 inhibitor SureCN4822166 fa... 1 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 9 1
Dihydrofolate reductase inhibitor 4-[[4-(4,6-diamino-2,2-dimet... 1 1
Major prion protein and Microtubule-associated protein tau inh... 2 10
RAF proto-oncogene serine/threonine-protein kinase inhibitor 3... 1 0
Nuclear receptor ROR-gamma and Lethal factor ligand NSC211094 ... 1 3
Glucagon receptor ligand 2-chloro-N-[[3-chloro-4-(4-chlorophen... 1 7
Beta-lactamase and Microtubule-associated protein tau inhibito... 1 1
N-(4-acetamidophenyl)-2-(2,2-dimethyl-3,4-dihydrochromen-6-yl)... 1 0
Putative NP ZINC09660123 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400558 CHEMBL2017807 Bioactive 2-methoxy-N-[(4-phenyl-3-propan-2-ylphenyl)carbamoyl]benzamide
CFAMM00400548 CHEMBL2017811 Bioactive 2-methoxy-N-[[4-(2,2,2-trifluoroethoxy)-3-(trifluoromethyl)phenyl]carbamoyl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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