CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10244
Family Name Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]-N-hydroxybenzamide family
No. of Seeds 2 No. of Other Members 9
Family Centroid CFAMM00400659 Functional Category Bioactive
Superfamily Histone deacetylase 6 and Histone deacetylase 1 Binder Superfamily
Class Class 1555

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Setipiprant family 5 118
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Transient receptor potential cation channel subfamily V member... 6 23
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 3 14
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Cannabinoid receptor 1 ligand 5-cyano-1-[(3,5-dichlorophenyl)m... 2 0
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 2 5
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 1 1
Substance-P receptor ligand SureCN7796965 family 9 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Prostaglandin D2 receptor 2 and Prostaglandin G/H synthase 1 l... 3 17
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(3-chlorophenyl)-meth... 1 0
Prostaglandin D2 receptor 2 and Cytochrome P450 2C19 ligand 2-... 6 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Coagulation factor X inhibitor ethyl (3R,4S)-3-[(3-chloro-1H-i... 5 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Substance-P receptor ligand AGN-PC-004REJ family 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Glycogen phosphorylase, liver form inhibitor 2-[(1R,2R)-2-[(5-... 3 2
Neuromedin-K receptor ligand AGN-PC-00GCXP family 3 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400655 CHEMBL2386066 Bioactive 2-(2-benzoyl-8-chloro-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)acetic acid
CFAMM00400659 CHEMBL2018300 Bioactive 4-[(8-chloro-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]-N-hydroxybenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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