CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10247
Family Name C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-2-(methylcarbamoylamino)-5-(trifluoromethyl)benzamide family
No. of Seeds 13 No. of Other Members 8
Family Centroid CFAMM00400684 Functional Category Bioactive
Superfamily Granotapide Superfamily
Class Class 1380

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Kappa-type opioid receptor Ligand Asimadoline Family 14 54
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Pol polyprotein inhibitor 3-[(4R,5R,6R)-4-benzyl-3-(3-carbamoy... 3 1
Melanin-concentrating hormone receptor 1 ligand 1-[4-(3-cyanop... 4 9
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 11 9
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Sphingosine 1-phosphate receptor 1 ligand 7-(2-hydroxyethyl)-1... 2 10
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1
Pol polyprotein inhibitor 2,5-bis[(2-{[(benzyloxy)carbonyl]ami... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 1 1
C-C chemokine receptor type 2 ligand AGN-PC-03L0X5 family 13 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Beta-secretase 1 and Beta-secretase 2 inhibitor AC1N6ZLA family 1 0
Glycogen phosphorylase, liver form inhibitor SureCN5195475 family 9 5
Pol polyprotein inhibitor 3-amino-N-[(2S,3S,4R,5S)-5-[(3-amino... 2 1
Glycogen phosphorylase, liver form inhibitor AGN-PC-00CDLB family 2 0
Vasopressin V2 receptor ligand SureCN4206215 family 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Angiotensin-converting enzyme inhibitor (6aS,8R)-5-[(3-bromoph... 2 4
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12
NP (s)-methyl 2-(3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1... 11 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400680 CHEMBL2018388 Bioactive N-[2-[[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]azetidine-1-carboxamide
CFAMM00400673 CHEMBL2018394 Bioactive 2-(benzylamino)-N-[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CFAMM00400686 CHEMBL2018381 Bioactive 2-amino-N-[2-[[(2S,3R)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CFAMM00400685 CHEMBL2018380 Bioactive 2-amino-N-[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CFAMM00400684 CHEMBL2018385 Bioactive N-[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-2-(methylcarbamoylamino)-5-(trifluoromethyl)benzamide
CFAMM00400677 CHEMBL2018392 Bioactive N-[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-2-(propan-2-ylamino)-5-(trifluoromethyl)benzamide
CFAMM00400683 CHEMBL2018384 Bioactive tert-butyl N-[2-[[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]carbamate
CFAMM00400676 CHEMBL2018393 Bioactive 2-(tert-butylamino)-N-[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CFAMM00400682 CHEMBL2018387 Bioactive N-[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-2-(propan-2-ylcarbamoylamino)-5-(trifluoromethyl)benzamide
CFAMM00400675 CHEMBL2018390 Bioactive N-[2-[[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]morpholine-4-carboxamide
CFAMM00400681 CHEMBL2018389 Bioactive N-[2-[[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]pyrrolidine-1-carboxamide
CFAMM00400674 CHEMBL2018391 Bioactive N-[2-[[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]carbamoyl]-4-(trifluoromethyl)phenyl]piperazine-1-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543