CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10249
Family Name C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluoromethyl)phenyl]-N'-[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]propanediamide family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00400695 Functional Category Bioactive
Superfamily Acyl-CoA desaturase and Acyl-CoA desaturase 1 Inhibitor CVT-12012 Superfamily
Class Class 933

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Kappa-type opioid receptor and Cytochrome P450 2D6 ligand Sure... 11 9
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Glycogen phosphorylase, liver form inhibitor SureCN5195475 family 9 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400693 CHEMBL2018402 Bioactive N'-[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]-N-[3-(ethylamino)-5-(trifluoromethyl)phenyl]propanediamide
CFAMM00400692 CHEMBL2018401 Bioactive N'-[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]-N-[3-(methylamino)-5-(trifluoromethyl)phenyl]propanediamide
CFAMM00400691 CHEMBL2018396 Bioactive 3-amino-N-[2-[[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]amino]-2-oxoethyl]-5-(trifluoromethyl)benzamide
CFAMM00400695 CHEMBL2018400 Bioactive N-[3-amino-5-(trifluoromethyl)phenyl]-N'-[(2S,3S)-1-[(2,4-dimethylphenyl)methylamino]-3-hydroxyhexan-2-yl]propanediamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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