CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1025
Family Name Beta-secretase 1 inhibitor N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-5-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-5-oxopentanamide family
No. of Seeds 1 No. of Other Members 2
Family Centroid CFAMM00318575 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin D Binder Superfamily
Class Class 168

Cousin Family NamesSeedsMembers
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Pol polyprotein inhibitor 169168-45-0 family 7 11
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Beta-secretase 1 inhibitor N-[(1S,2S)-1-[(2R)-4-benzylsulfonyl... 2 0
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1


External ID

Functional Category

Molecule Name

CFAMM00318575 CHEMBL1097343 Bioactive N-[(1S,2S)-3-(3,5-difluorophenyl)-1-hydroxy-1-[(2R)-4-(3-methylphenyl)sulfonylpiperazin-2-yl]propan-2-yl]-5-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]-5-oxopentanamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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