CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10250
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)-1-N-cyclohexyl-2-N-[3-(1H-imidazol-5-yl)propyl]piperazine-1,2-dicarboxamide family
No. of Seeds 4 No. of Other Members 1
Family Centroid CFAMM00400699 Functional Category Bioactive
Superfamily Protein farnesyltransferase subunit beta and Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Binder Superfamily 4
Class Class 1033

Cousin Family NamesSeedsMembers
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Somatostatin receptor type 4 and Glucosylceramidase ligand MLS... 1 16
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 10 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1


CFAM Mol ID

External ID

Functional Category

Molecule Name
CFAMM00400698 CHEMBL381360 Bioactive AGN-PC-075Z5B
CFAMM00400697 CHEMBL201844 Bioactive 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)-1-N-cyclohexyl-2-N-[2-(1H-imidazol-5-yl)ethyl]piperazine-1,2-dicarboxamide
CFAMM00400696 CHEMBL371962 Bioactive 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)-1-N-cyclohexyl-2-N-[2-(3-methylimidazol-4-yl)ethyl]piperazine-1,2-dicarboxamide
CFAMM00400699 CHEMBL201903 Bioactive 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[1,2]cyclohepta[2,4-b]pyridin-11-yl)-1-N-cyclohexyl-2-N-[3-(1H-imidazol-5-yl)propyl]piperazine-1,2-dicarboxamide

Statistics of CFAM Database
 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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