CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1026
Family Name Beta-secretase 1 inhibitor N-[(1S,2S)-1-[(2R)-4-benzylsulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00318578 Functional Category Bioactive
Superfamily Beta-secretase 1 and Cathepsin B Binder Superfamily
Class Class 3128

Cousin Family NamesSeedsMembers
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Plasmepsin-2 Inhibitor PS-222036 Family 12 134
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Beta-secretase 1 and Cathepsin D inhibitor (1R,3S)-N-[(2S,3S)-... 2 25
Beta-secretase 1 inhibitor SureCN8292705 family 7 6
Beta-secretase 1 inhibitor SureCN8293614 family 2 0
Beta-secretase 1 inhibitor N-[(1S,2S)-3-(3,5-difluorophenyl)-1... 1 2
Pol polyprotein inhibitor 2-[(2R,3S)-3-[[(2R)-3-(benzenesulfin... 15 15
Pol polyprotein inhibitor 152928-55-7 family 23 2
Beta-secretase 1 and Cathepsin B inhibitor SureCN4666465 family 9 4
Beta-secretase 1 inhibitor 1-N-[(1R,2S)-1-[(2R,4S)-4-butoxypip... 5 1
Beta-secretase 1 and Cathepsin D inhibitor (4S)-N-[(2S,3R)-4-[... 3 0
Beta-secretase 1 and Cathepsin B inhibitor 3-chloro-N-[(2S)-1-... 2 0
Beta-secretase 1 and Cathepsin E inhibitor 1-N-[(1R,2S)-3-(3,5... 3 8
Pol polyprotein inhibitor AC1LAMTC family 6 0
Substance-P receptor ligand AGN-PC-03I9DJ family 3 0
Pol polyprotein inhibitor Enantiomer of AG1284 family 7 1
Beta-secretase 1 inhibitor SureCN8292004 family 1 0
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00318578 CHEMBL1097353 Bioactive N-[(1S,2S)-1-[(2R)-4-benzylsulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide
CFAMM00318577 CHEMBL1097354 Bioactive N-[(1S,2S)-1-[(2R)-4-cyclopropylsulfonylpiperazin-2-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]-3-[(2R)-2-(methoxymethyl)pyrrolidine-1-carbonyl]-5-methylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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