CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10268
Family Name Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(1,2,3,4-tetrahydroacridin-9-ylamino)nonyl]chromene-2-carboxamide;hydrochloride family
No. of Seeds 11 No. of Other Members 13
Family Centroid CFAMM00261455 Functional Category Bioactive
Superfamily Acetylcholinesterase and Cholinesterase Binder Superfamily 2
Class Class 3421

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... 26 101
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... 4 24
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Renin inhibitor [2-(2,6-dimethylphenoxy)-6-methoxy-1-phenylpyr... 1 0
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Acetylcholinesterase and Cholinesterase inhibitor N-[10-[(6-ch... 6 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Acetylcholinesterase and Cholinesterase inhibitor 5-methoxy-7-... 1 18
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-073E7... 2 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Cellular tumor antigen p53 inhibitor CHEMBL1518986 family 1 1
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00400846 CHEMBL2019044 Bioactive N-[10-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-6-hydroxy-4-oxochromene-2-carboxamide;hydrochloride
CFAMM00400838 CHEMBL2019035 Bioactive N-[10-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-6-methoxy-4-oxochromene-2-carboxamide;hydrochloride
CFAMM00400844 CHEMBL2019043 Bioactive 6-hydroxy-4-oxo-N-[10-(1,2,3,4-tetrahydroacridin-9-ylamino)decyl]chromene-2-carboxamide;hydrochloride
CFAMM00400837 CHEMBL2019036 Bioactive N-[10-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-6-methoxy-4-oxochromene-2-carboxamide;hydrochloride
CFAMM00400836 CHEMBL2019032 Bioactive N-[10-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-4-oxochromene-2-carboxamide;hydrochloride

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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