CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10279
Family Name Caspase-1 inhibitor (3S)-4-oxo-3-[[6-[[4-(quinoxalin-2-ylamino)benzoyl]amino]-2-thiophen-2-ylhexanoyl]amino]butanoic acid family
No. of Seeds 5 No. of Other Members 6
Family Centroid CFAMM00400979 Functional Category Bioactive
Superfamily Thrombopoietin receptor and Follicle-stimulating hormone receptor Binder Superfamily
Class Class 170

Cousin Family NamesSeedsMembers
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Dihydrofolate reductase inhibitor AGN-PC-075RRH family 2 3
Vascular endothelial growth factor receptor 1 and Receptor-typ... 1 0
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Melanin-concentrating hormone receptor 1 and Muscarinic acetyl... 8 2
Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methy... 2 0
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Calcitonin gene-related peptide type 1 receptor ligand N-(1-me... 1 3


External ID

Functional Category

Molecule Name

CFAMM00400972 CHEMBL444088 Bioactive (3S)-4-oxo-3-[[2-phenyl-6-[[4-(quinoxalin-2-ylamino)benzoyl]amino]hexanoyl]amino]butanoic acid
CFAMM00400978 CHEMBL202044 Bioactive (3S)-3-[[6-[[3-methyl-4-(quinoxalin-2-ylamino)benzoyl]amino]-2-thiophen-2-ylhexanoyl]amino]-4-oxobutanoic acid
CFAMM00400981 CHEMBL373061 Bioactive (3S)-3-[[6-[[4-[(6-methylquinoxalin-2-yl)amino]benzoyl]amino]-2-thiophen-2-ylhexanoyl]amino]-4-oxobutanoic acid
CFAMM00400980 CHEMBL202100 Bioactive (3S)-3-[[2-(2-fluorophenyl)-6-[[4-(quinoxalin-2-ylamino)benzoyl]amino]hexanoyl]amino]-4-oxobutanoic acid
CFAMM00400979 CHEMBL202060 Bioactive (3S)-4-oxo-3-[[6-[[4-(quinoxalin-2-ylamino)benzoyl]amino]-2-thiophen-2-ylhexanoyl]amino]butanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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