CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM10283
Family Name Muscarinic acetylcholine receptor M2 and Muscarinic acetylcholine receptor M4 ligand 11-[2-[[(1R,2R)-2-(dimethylamino)cyclohexyl]-methylamino]acetyl]-5H-benzo[b][1,4]benzodiazepin-6-one;oxalic acid family
No. of Seeds 5 No. of Other Members 19
Family Centroid CFAMM00187549 Functional Category Bioactive with Natural Product
Superfamily Vasopressin V2 receptor and Vasopressin V1a receptor Binder Superfamily
Class Class 1365

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Integrin beta-3 Inhibitor Lotrafiban Family 5 1
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Vasopressin V1a receptor ligand AGN-PC-074VSA family 3 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Urokinase plasminogen activator surface receptor ligand 5,12-d... 1 0
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 1
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Aldose reductase inhibitor (4R)-6-fluoro-3-methylspiro[1H-quin... 4 16
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN4854179 f... 1 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12
NP Methyl 2-(5,11-dioxo-2,3,11,11a-tetrahydro-1h-benzo[e]pyrro... 2 1
1,3,3a,5-tetrahydro-[1,3]thiazolo[4,3-c][1,4]benzodiazepine-4,... 3 1
NP (s)-methyl 2-(3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1... 11 3
Putative NP ZINC32124058 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00401031 CHEMBL355874 Bioactive 11-[2-[4-[4-(ethylamino)butyl]piperidin-1-yl]acetyl]-5H-benzo[b][1,4]benzodiazepin-6-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27257 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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